Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…
Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…
Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…
Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…
Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…
Keywords Infliximab, TNF-α, Psoriasis, SPIRIT, EXPRESS, EXPRESS II, IMPACT Key points • Infliximab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of…
Keywords Cyclosporine, CsA, Neoral, Sandimmune, PISCES, PREWENT Key points • Cyclosporine (CsA) is a highly effective treatment option for patients with moderate-to-severe plaque psoriasis with a rapid onset of…
Keywords Methotrexate, MTX, Folate antagonist, CHAMPION, RESTORE1 Key points • Methotrexate (MTX) remains a safe and effective modality for the treatment of severe, recalcitrant psoriasis when used appropriately. •…
Keywords Psoralen-UV-A, PUVA, Photochemotherapy, Psoriasis Key points • Psoralen-UV-A (PUVA) photochemotherapy involves use of either an oral or topical psoralen followed by exposure to long-wave UV-A radiation. This combination…
