Surgical Therapy for Transmen

Jul 8, 2019 by in General Surgery Comments Off on Surgical Therapy for Transmen

Chest surgery Chest-wall contouring is an important, early surgical step for transmen and may help to facilitate their transition. The goals of chest surgery include the aesthetic contouring of the…

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Surgical Therapy for Transwomen

Jul 8, 2019 by in General Surgery Comments Off on Surgical Therapy for Transwomen

Surgical conversion of the genitalia in transwomen has evolved since the use of skin grafts for creation of a neovagina in cases of vaginal agenesis. The use of pedicled penile…

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Surgical Therapy

Jul 8, 2019 by in General Surgery Comments Off on Surgical Therapy

Embryology Genetic sex is determined at fertilization, either XX or XY. For the first 6 weeks of development, gender is not distinguishable, and this is known as the indifferent period. Characteristic…

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Medical Therapy

Jul 8, 2019 by in General Surgery Comments Off on Medical Therapy

Diagnosis Transgender is not a formal diagnosis. Transgender individuals possess persistent concerns, uncertainties, and questions about gender identity. These issues often become the most important aspect of their life and…

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Background

Jul 8, 2019 by in General Surgery Comments Off on Background

Definitions Gender Dysphoria The term gender dysphoria describes a heterogeneous group of individuals who express varying degrees of discomfort with or disassociation from their anatomic gender. Some people with this…

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Ixekizumab

Jun 23, 2019 by in General Surgery Comments Off on Ixekizumab

Keywords Ixekizumab, Taltz, Interleukin-17A, Monoclonal antibody, UNCOVER-2, UNCOVER-3   Key points • Ixekizumab is a humanized monoclonal antibody against interleukin-17A. • Ixekizumab is more efficacious in the treatment of plaque…

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Investigational Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Investigational Therapies for Psoriasis

Keywords Janus kinase, Tumor necrosis factor-α, Interleukin-17, Interleukin-23   Key points • Investigational therapies aim to inhibit the specific immunologic mechanisms behind plaque psoriasis without widely affecting the normal immune…

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Biosimilars

Jun 23, 2019 by in General Surgery Comments Off on Biosimilars

Keywords Biosimilar, Inflectra, Remsima, CT-P13, Infliximab-dyyb   Key points • Through the Biologics Price Competition and Innovation act, the US Food and Drug Administration (FDA) has defined a biosimilar as…

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Combination Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Combination Therapies for Psoriasis

Keywords Psoriasis, Combination, Acitretin, Cyclosporine, Methotrexate, Biologics, Etanercept, Adalimumab   Key points • Combination therapies of biologics and systemic agents for psoriasis treatment can potentially enhance efficacy of treatment, increase…

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Secukinumab

Jun 23, 2019 by in General Surgery Comments Off on Secukinumab

Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE   Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…

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