Ixekizumab

Jun 23, 2019 by in General Surgery Comments Off on Ixekizumab

Keywords Ixekizumab, Taltz, Interleukin-17A, Monoclonal antibody, UNCOVER-2, UNCOVER-3   Key points • Ixekizumab is a humanized monoclonal antibody against interleukin-17A. • Ixekizumab is more efficacious in the treatment of plaque…

read more

Investigational Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Investigational Therapies for Psoriasis

Keywords Janus kinase, Tumor necrosis factor-α, Interleukin-17, Interleukin-23   Key points • Investigational therapies aim to inhibit the specific immunologic mechanisms behind plaque psoriasis without widely affecting the normal immune…

read more

Biosimilars

Jun 23, 2019 by in General Surgery Comments Off on Biosimilars

Keywords Biosimilar, Inflectra, Remsima, CT-P13, Infliximab-dyyb   Key points • Through the Biologics Price Competition and Innovation act, the US Food and Drug Administration (FDA) has defined a biosimilar as…

read more

Combination Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Combination Therapies for Psoriasis

Keywords Psoriasis, Combination, Acitretin, Cyclosporine, Methotrexate, Biologics, Etanercept, Adalimumab   Key points • Combination therapies of biologics and systemic agents for psoriasis treatment can potentially enhance efficacy of treatment, increase…

read more

Secukinumab

Jun 23, 2019 by in General Surgery Comments Off on Secukinumab

Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE   Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…

read more

Adalimumab

Jun 23, 2019 by in General Surgery Comments Off on Adalimumab

Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT   Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…

read more

Ustekinumab

Jun 23, 2019 by in General Surgery Comments Off on Ustekinumab

Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI   Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…

read more

Etanercept

Jun 23, 2019 by in General Surgery Comments Off on Etanercept

Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic   Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…

read more

Apremilast

Jun 23, 2019 by in General Surgery Comments Off on Apremilast

Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis   Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…

read more

Infliximab

Jun 23, 2019 by in General Surgery Comments Off on Infliximab

Keywords Infliximab, TNF-α, Psoriasis, SPIRIT, EXPRESS, EXPRESS II, IMPACT   Key points • Infliximab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of…

read more
Get Clinical Tree app for offline access