Microvasculature
Key points • Cutaneous microcirculation, a type of microvasculature situated just below the epidermis, is composed of major components of blood vessels (arterioles and venules) and lymphatic vessels. • The…
Wound Care
Key points • Issues with wound healing in patients with atopic dermatitis (AD) relate to innate inability to repair the barrier, defective angiogenesis, abnormal microbial colonization, and a prolonged inflammatory…
Skin-Gut-Lung Epithelial Permeability
Key points • The atopic march is a phenomenon characterized by progressive development of atopic dermatitis, food allergy, allergic rhinitis, and later asthma. • The mechanism by which atopic dermatitis…
Complementary and Alternative Approaches II
Key points • A review of a variety of alternative therapies for atopic dermatitis (AD) is the focus of this chapter. Among those reviewed are acupuncture, cupping, and herbal therapies,…
Complementary and Alternative Approaches I
Key points • Current first-line conventional treatments for atopic dermatitis include topical corticosteroids, emollients, and topical and/or systemic immunomodulators (e.g., dupilumab). • However, a majority of patients with atopic dermatitis…
Itch and Pain Treatments
Key points • Itch and pain are key symptoms of atopic dermatitis (AD) that significantly affect quality of life; various classes of treatment aim to reduce these symptoms. • Nonpharmacologic…
Emerging Targeted Treatments
Key points • This chapter provides an overview of the pathogenesis of atopic dermatitis and the key mediators that are of therapeutic interest. • As we acquire more knowledge into…
Skin Barrier Repair
Key points • Moisturizers help with skin barrier repair and continue to be the mainstay of maintenance treatment and prevention of flares in atopic dermatitis (AD). • Though greasier moisturizer…
Cellular Factors
Key points • Atopic dermatitis (AD) is a complex disease with various types of leukocytes involved in its pathology. • Multiple subsets of CD4 + helper T cells, which are…
Therapeutic Guideline Overview
Key points • Multiple clinical guidelines, consensus statements, and expert management recommendations have been published for atopic dermatitis. • Most prominent guidelines are from the American Academy of Dermatology and…
