Dermatology

Microvasculature

Jun 18, 2022 by in Dermatology Comments Off on Microvasculature

Key points • Cutaneous microcirculation, a type of microvasculature situated just below the epidermis, is composed of major components of blood vessels (arterioles and venules) and lymphatic vessels. • The…

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Wound Care

Jun 18, 2022 by in Dermatology Comments Off on Wound Care

Key points • Issues with wound healing in patients with atopic dermatitis (AD) relate to innate inability to repair the barrier, defective angiogenesis, abnormal microbial colonization, and a prolonged inflammatory…

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Skin-Gut-Lung Epithelial Permeability

Jun 18, 2022 by in Dermatology Comments Off on Skin-Gut-Lung Epithelial Permeability

Key points • The atopic march is a phenomenon characterized by progressive development of atopic dermatitis, food allergy, allergic rhinitis, and later asthma. • The mechanism by which atopic dermatitis…

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Complementary and Alternative Approaches I

Jun 18, 2022 by in Dermatology Comments Off on Complementary and Alternative Approaches I

Key points • Current first-line conventional treatments for atopic dermatitis include topical corticosteroids, emollients, and topical and/or systemic immunomodulators (e.g., dupilumab). • However, a majority of patients with atopic dermatitis…

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Itch and Pain Treatments

Jun 18, 2022 by in Dermatology Comments Off on Itch and Pain Treatments

Key points • Itch and pain are key symptoms of atopic dermatitis (AD) that significantly affect quality of life; various classes of treatment aim to reduce these symptoms. • Nonpharmacologic…

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Emerging Targeted Treatments

Jun 18, 2022 by in Dermatology Comments Off on Emerging Targeted Treatments

Key points • This chapter provides an overview of the pathogenesis of atopic dermatitis and the key mediators that are of therapeutic interest. • As we acquire more knowledge into…

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Skin Barrier Repair

Jun 18, 2022 by in Dermatology Comments Off on Skin Barrier Repair

Key points • Moisturizers help with skin barrier repair and continue to be the mainstay of maintenance treatment and prevention of flares in atopic dermatitis (AD). • Though greasier moisturizer…

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Cellular Factors

Jun 18, 2022 by in Dermatology Comments Off on Cellular Factors

Key points • Atopic dermatitis (AD) is a complex disease with various types of leukocytes involved in its pathology. • Multiple subsets of CD4 + helper T cells, which are…

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Therapeutic Guideline Overview

Jun 18, 2022 by in Dermatology Comments Off on Therapeutic Guideline Overview

Key points • Multiple clinical guidelines, consensus statements, and expert management recommendations have been published for atopic dermatitis. • Most prominent guidelines are from the American Academy of Dermatology and…

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