General Surgery

Ixekizumab

Jun 23, 2019 by in General Surgery Comments Off on Ixekizumab

Keywords Ixekizumab, Taltz, Interleukin-17A, Monoclonal antibody, UNCOVER-2, UNCOVER-3   Key points • Ixekizumab is a humanized monoclonal antibody against interleukin-17A. • Ixekizumab is more efficacious in the treatment of plaque…

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Investigational Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Investigational Therapies for Psoriasis

Keywords Janus kinase, Tumor necrosis factor-α, Interleukin-17, Interleukin-23   Key points • Investigational therapies aim to inhibit the specific immunologic mechanisms behind plaque psoriasis without widely affecting the normal immune…

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Biosimilars

Jun 23, 2019 by in General Surgery Comments Off on Biosimilars

Keywords Biosimilar, Inflectra, Remsima, CT-P13, Infliximab-dyyb   Key points • Through the Biologics Price Competition and Innovation act, the US Food and Drug Administration (FDA) has defined a biosimilar as…

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Combination Therapies for Psoriasis

Jun 23, 2019 by in General Surgery Comments Off on Combination Therapies for Psoriasis

Keywords Psoriasis, Combination, Acitretin, Cyclosporine, Methotrexate, Biologics, Etanercept, Adalimumab   Key points • Combination therapies of biologics and systemic agents for psoriasis treatment can potentially enhance efficacy of treatment, increase…

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Secukinumab

Jun 23, 2019 by in General Surgery Comments Off on Secukinumab

Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE   Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…

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Adalimumab

Jun 23, 2019 by in General Surgery Comments Off on Adalimumab

Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT   Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…

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Ustekinumab

Jun 23, 2019 by in General Surgery Comments Off on Ustekinumab

Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI   Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…

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Etanercept

Jun 23, 2019 by in General Surgery Comments Off on Etanercept

Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic   Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…

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Apremilast

Jun 23, 2019 by in General Surgery Comments Off on Apremilast

Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis   Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…

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Infliximab

Jun 23, 2019 by in General Surgery Comments Off on Infliximab

Keywords Infliximab, TNF-α, Psoriasis, SPIRIT, EXPRESS, EXPRESS II, IMPACT   Key points • Infliximab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of…

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