Topical Therapies

Jun 18, 2022 by in Dermatology Comments Off on Topical Therapies

Key points • Optimal bathing practices can improve atopic dermatitis (AD) symptoms and limit disease flares. Best practices include daily bathing for less than 10 minutes in lukewarm water, utilizing…

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Clinical Evidence: Internal Factors

Jun 18, 2022 by in Dermatology Comments Off on Clinical Evidence: Internal Factors

Key points • Less than 50% of patients affected with atopic dermatitis have a genetic mutation of the skin barrier protein, filaggrin. Thus additional contributing factors, barrier defects, and beyond…

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Neurosensory Mechanisms

Jun 18, 2022 by in Dermatology Comments Off on Neurosensory Mechanisms

Key points • Both itch and pain are very frequent symptoms in patients with atopic dermatitis, with a prevalence of more than 50%. • Patients with atopic dermatitis show neuronal…

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Clinical Evidence: External Factors

Jun 18, 2022 by in Dermatology Comments Off on Clinical Evidence: External Factors

Key points • The fact that up to 50% of atopic dermatitis (AD) patients have loss-of-function genetic mutations of skin barrier protein filaggrin points to a cutaneous weakness that allows…

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Epigenetics

Jun 18, 2022 by in Dermatology Comments Off on Epigenetics

Key points • There are three major types of epigenetic modifications: DNA methylation, microRNAs, and posttranslational histone modifications. • DNA methylation and microRNAs alter the expression of atopic dermatitis-associated genes…

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Immunogens

Jun 18, 2022 by in Dermatology Comments Off on Immunogens

Key points • Patients with atopic dermatitis are more susceptible to developing irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD). • ICD can present with phenotypic subtypes such as…

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Humoral Factors

Jun 18, 2022 by in Dermatology Comments Off on Humoral Factors

Key points • Allergen-specific B cells are differentiated into plasma cells producing immunoglobulin E (IgE) antibodies. Through binding to the receptors (FcεRI and FcεRII), IgE induces cytokine and chemokine production…

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Nutrition

Jun 18, 2022 by in Dermatology Comments Off on Nutrition

Key points • Maternal supplementation of omega-3 polyunsaturated fatty acids may reduce risk of atopic dermatitis (AD). • Fish intake during early childhood may decrease the risk of developing AD….

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Atopy of the Skin

Jun 18, 2022 by in Dermatology Comments Off on Atopy of the Skin

Key points • Atopy of the skin is manifested as atopic dermatitis (atopic eczema). • Histologically, the atopy of the skin is characterized by epidermal and dermal infiltration predominantly by…

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