Adalimumab

Jun 23, 2019 by in General Surgery Comments Off on Adalimumab

Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT   Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…

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Ustekinumab

Jun 23, 2019 by in General Surgery Comments Off on Ustekinumab

Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI   Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…

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Etanercept

Jun 23, 2019 by in General Surgery Comments Off on Etanercept

Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic   Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…

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Apremilast

Jun 23, 2019 by in General Surgery Comments Off on Apremilast

Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis   Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…

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Infliximab

Jun 23, 2019 by in General Surgery Comments Off on Infliximab

Keywords Infliximab, TNF-α, Psoriasis, SPIRIT, EXPRESS, EXPRESS II, IMPACT   Key points • Infliximab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of…

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Cyclosporine

Jun 23, 2019 by in General Surgery Comments Off on Cyclosporine

Keywords Cyclosporine, CsA, Neoral, Sandimmune, PISCES, PREWENT   Key points • Cyclosporine (CsA) is a highly effective treatment option for patients with moderate-to-severe plaque psoriasis with a rapid onset of…

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Acitretin

Jun 23, 2019 by in General Surgery Comments Off on Acitretin

Keywords Acitretin, Etretinate, Phototherapy, PUVA, Broadband UV-B, Narrowband UV-B, Teratogenic, Hyperlipidemia   Key points • Acitretin is an effective agent for the treatment of plaque psoriasis and is often used…

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Methotrexate

Jun 23, 2019 by in General Surgery Comments Off on Methotrexate

Keywords Methotrexate, MTX, Folate antagonist, CHAMPION, RESTORE1   Key points • Methotrexate (MTX) remains a safe and effective modality for the treatment of severe, recalcitrant psoriasis when used appropriately. •…

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Psoralen-Ultraviolet Light A Therapy

Jun 23, 2019 by in General Surgery Comments Off on Psoralen-Ultraviolet Light A Therapy

Keywords Psoralen-UV-A, PUVA, Photochemotherapy, Psoriasis   Key points • Psoralen-UV-A (PUVA) photochemotherapy involves use of either an oral or topical psoralen followed by exposure to long-wave UV-A radiation. This combination…

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Ultraviolet B Phototherapy

Jun 23, 2019 by in General Surgery Comments Off on Ultraviolet B Phototherapy

Keywords Phototherapy, Narrowband UV-B, UV therapy, Psoriasis, Excimer laser   Key points • Phototherapy with UV light can be used in the treatment of several cutaneous disorders. • Phototherapy is…

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