Abstract Systemic sclerosis (SSc, scleroderma) is an uncommon autoimmune connective tissue disease of unknown etiology. The clinical hallmark of the disease is cutaneous sclerosis. Ninety-five percent of SSc patients present…
Abstract The cutaneous amyloidoses represent a heterogeneous group of conditions in which amyloid, a fibrillar material that can result from the degradation of various proteins, is deposited in the skin….
Abstract The clinicopathologic features of the following entities are reviewed: systemic-onset juvenile idiopathic arthritis (sJIA), adult-onset Still disease, relapsing polychondritis, Sjögren syndrome, mixed connective tissue disease (MCTD), and rheumatoid arthritis,…
Abstract The cutaneous deposition disorders are a heterogeneous group of conditions characterized by the presence of primarily endogenous substances within the dermis and/or the subcutis. These include gout, pseudogout, lipoid…
Abstract Dermatomyositis is an autoimmune disease that most often affects both the muscles and the skin (classic dermatomyositis), but also may occur in a skin-predominant fashion (clinically amyopathic dermatomyositis). All…
Abstract This chapter reviews both superficial and deep forms of folliculitis as well as disorders of follicular keratinization and the follicular occlusion tetrad (acne conglobata, hidradenitis suppurativa, dissecting cellulitis, and…
Abstract Rosacea is a common chronic facial dermatosis, most often affecting individuals with lighter skin phototypes and first appearing during middle age. Proposed pathomechanisms include abnormal cutaneous innate immune responses…
Abstract Inherited epidermolysis bullosa (EB) represents a group of genetic disorders characterized by mechanically fragile skin with a propensity to develop blisters and/or erosions. EB simplex, junctional EB, dystrophic EB…
Abstract Acne vulgaris is one of the skin disorders most frequently encountered by dermatologists as well as primary care providers. It is especially common in adolescents but also occurs in…
