Fig. 16.1 Diagram over a normal epidermis showing the location of the microscopic vesicles in the different autoimmune blistering diseases (hematoxylin-eosin stain; original magnification ×200) 16.1.1 Intraepidermal Blistering Diseases 16.1.1.1…
Fig. 19.1 Electron micrograph illustrating key components of a desmosome (a, b) and a normal anchoring complex (c, d): tonofilaments (tf), attachment plaque of tf in desmosomes (arrow head), hemidesmosome…
Fig. 35.1 Blisters surrounded by erythema on the gingiva and area of normal mucous membrane Fig. 35.2 Erythema and large flaccid bullous lesions on the soft palate Fig. 35.3 The…
Mode of inheritance Gene Target protein AD = autosomal dominant AR = autosomal recessive Dominant DEB Dominant DEB, generalized AD COL7A1 Type VII collagen Dominant DEB, acral AD, AR…
Fig. 24.1 Oral mucosa involvement in pemphigus vulgaris. Erosions on the tongue Fig. 24.2 Oral mucosa involvement in pemphigus vulgaris. Erosions on the lip Fig. 24.3 Oral mucosa involvement in…
Form of EB Lin et al. [6] Tong et al. [7] Simplex EB 3 % 12 % Junctional EB 39 % 40 % Recessive dystrophic EB 51 % 51 %…
Acquired immunobullous diseases (AIBD) Antigen mapping (AgM) 1. Level of split formation Intraepidermal, junctional, dermolytic Autoantibody mapping (AbM) = salt split skin test (SSST) 2. Location of binding of autoantibodies…
Fig. 31.1 Classical bullous pemphigoid with tense bullae on the limb surrounded by erythema with infiltrated confluent urticarial plaques. Vesicles and eroded and crusted lesions are also observed Fig. 31.2…
Vancomycin – most common Captopril Trimethoprim/sulfamethoxazole Phenytoin Diclofenac The most common disease associated with LABD is ulcerative colitis. The relationship is unclear, and abnormal IgA1 production in the gastrointestinal tract…
Fig. 30.1 Palmoplantar keratoderma in EBS Fig. 30.2 Tense blistering, hyperkeratosis and thickened nails in a boy with EBS gen-se Fig. 30.3 Koebnerization in EBS In localised EBS, blistering is…
