Abstract Basement membranes represent highly specialized matrices at the interface of cells and stroma. As adhesive units composed of intricately organized intracellular, transmembrane, and extracellular proteins, basement membranes provide tissues…
Abstract The skin is one of the most common targets for adverse drug reactions. Approximately 2% of all drug-induced skin reactions are considered “serious” based upon the World Health Organization…
Abstract A diverse array of entities can present with cutaneous vasculitis, and the characteristic skin findings reflect the caliber of inflamed blood vessel – small, medium-sized, or large. While cutaneous…
Abstract Microvascular occlusion in the skin may have distinctively patterned lesions, such as retiform purpura, and is clinically important to recognize and distinguish from cutaneous vasculitis in order to determine…
Abstract The eosinophil circulates as a mature cell in the blood and infiltrates tissue in response to certain signals. Eosinophils are found in various inflammatory and neoplastic dermatoses, including the…
Abstract Purpura is a sign of several different processes including trauma, thrombocytopenia, anticoagulant use, cutaneous small vessel vasculitis, septic emboli and vascular coagulopathies, and is due to cutaneous hemorrhage. The…
Abstract Until recently, the nosology of severe acute bullous disorders due to infectious agents or drugs has been confusing. It has now become clear that Stevens–Johnson syndrome (SJS) and toxic…
Abstract Urticaria is characterized by transient skin or mucosal swellings due to plasma leakage. When the swelling is superficial within the dermis, pruritic wheals appear, whereas when deep, angioedema is…
Abstract While there are multiple cutaneous disorders that can present with annular lesions, from urticaria to granuloma annulare, this chapter focuses on the four classic figurate erythemas – erythema annulare…
Abstract Allergic contact dermatitis (ACD) is caused by a delayed hypersensitivity reaction within the skin, manifesting as a pruritic dermatitis initially at the site of skin contact with the allergen….
