Pediatric Graft-Versus-Host Disease

Apr 13, 2018 by in Dermatology Comments Off on Pediatric Graft-Versus-Host Disease

Fig. 9.1 Pathophysiology of acute GVHD. IL 1 interleukin 1, IFN γ interferon γ, LPS lipopolysaccharide, Treg regulatory T cell, Th1 T-helper cell, CTL cytotoxic T lymphocyte [2]. Reprinted from…

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Cutaneous Reactions to Targeted Anticancer Agents

Apr 13, 2018 by in Dermatology Comments Off on Cutaneous Reactions to Targeted Anticancer Agents

Targeted anticancer agent Cutaneous adverse effects Treatment options EGFR inhibitors – Papulopustular eruption – Xerosis – Nail changes (paronychia, pyogenic granulomas) – Hair changes ( trichomegaly, hirsutism) – TCS, oral TCNs – Emollients – TCS or topical…

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Lymphoproliferative Disorders of the Skin

Apr 13, 2018 by in Dermatology Comments Off on Lymphoproliferative Disorders of the Skin

Fig. 3.1 Pseudolymphomatous folliculitis. Indurated erythematous nodule with associated follicular accentuation and scale on the forehead of an adolescent A special form of CLH that is more common in children…

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Malignant Soft Tissue Tumors in Children

Apr 13, 2018 by in Dermatology Comments Off on Malignant Soft Tissue Tumors in Children

Syndrome Gene mutation and inheritance Clinical features RMS type and/or features Other associated malignancies Li–Fraumeni P53 AD Early onset malignancy, familial Anaplastic RMS presents in children <3 years old • Breast…

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Malignancy-Associated Genodermatoses

Apr 13, 2018 by in Dermatology Comments Off on Malignancy-Associated Genodermatoses

Fig. 5.1 Numerous small skin-colored, dome-shaped papules on the neck, consistent with early basal cell carcinomas in Gorlin syndrome Fig. 5.2 Palmar pits , which can be subtle clinically but…

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Opportunistic Skin Infections in Immunosuppressed Children

Apr 13, 2018 by in Dermatology Comments Off on Opportunistic Skin Infections in Immunosuppressed Children

Fig. 10.1 Widespread cutaneous methicillin-sensitive Staphylococcus aureus infection in a renal transplant recipient (image courtesy of Carrie C. Coughlin, MD) Cellulitis is a superficial infection of the dermis and/or subcutaneous…

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Other Proliferative Disorders of the Skin

Apr 13, 2018 by in Dermatology Comments Off on Other Proliferative Disorders of the Skin

Classification Percent of pediatric cases (%) Description Associated signs and symptoms Prognosis Cutaneous solitary mastocytoma 20 Solitary macule or plaque with mast cell infiltrate Itching, lymphadenopathy Excellent: >90% show partial…

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Melanoma and Spitz Nevi in Children

Apr 13, 2018 by in Dermatology Comments Off on Melanoma and Spitz Nevi in Children

Fig. 1.1 Characteristic appearance of a Spitz nevus as a smooth dome-shaped pink papule [16]. Reprinted from Journal of the American Academy of Dermatology, Vol. 65, No. 6, Luo S,…

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