Abstract Heritable disorders of connective tissue comprise a phenotypically diverse group of conditions that often have multisystem involvement. These disorders can result from mutations in genes encoding structural elements of…
Abstract The perforating diseases are a group of disorders in which papulonodules develop due to transepidermal elimination of connective tissue or other substances. Two prototypes are reactive perforating collagenosis (RPC),…
Abstract Atrophies of the skin are caused by a diminution or loss of collagen and/or elastic fibers. These disorders range from common conditions, such as striae distensiae, to those conditions…
Abstract Examination of the oral soft and hard tissues may reveal signs of developmental anomalies, infectious or inflammatory conditions, and neoplastic processes. Alterations of the oral mucosa may also be…
Abstract Extracellular matrices (ECMs) consist of highly organized networks of collagens, elastin, glycoproteins, and proteoglycans. In addition to establishing tissue architecture and providing mechanical strength, ECMs are biologically active, regulating…
Abstract When implanted or injected into the skin, inorganic and high-molecular-weight organic materials can elicit a range of inflammatory reactions, from granulomatous to lichenoid to pseudolymphomatous. Less commonly, reactions resemble…
Abstract Pathologic reactions of the skin to light can arise from multiple etiologies including: immunologic photodermatoses, e.g. polymorphous light eruption, solar urticaria, actinic prurigo, hydroa vacciniforme, and chronic actinic dermatitis;…
Abstract Protozoal and helminth infections are major causes of tropical disease in many parts of the world. For some of the conditions, the clinical presentations differ depending on the geographic…
Abstract Physical, psychological, and sexual abuse may occur in any cultural environment. Although abuse is not limited to particular age groups, this chapter focuses on abuse and neglect inflicted upon…
Abstract This chapter covers the histiocytoses with emphasis on Langerhans cell histiocytosis (LCH) and many of the disorders comprising the large group of diseases referred to as non-Langerhans cell histiocytoses…
