Morphea and Lichen Sclerosus
Abstract Morphea and lichen sclerosus are inflammatory skin diseases that lead to cutaneous sclerosis, and in a number of patients, significant morbidity. The underlying pathogenesis is a combination of vascular…
Dermatology
Graft-versus-Host Disease
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for a variety of malignant and nonmalignant conditions. However, its use is limited by the risk of graft-versus-host…
Biology of Keratinocytes
Abstract The main function of the epidermis is to provide a barrier between the organism and the environment, thereby protecting against harmful substances and water loss. This barrier is the…
Nutritional Diseases
Abstract Proper nutrition is fundamental to human life. From fetal development to adulthood, proper nutrition is essential for survival, physical growth, mental development, productivity, and overall health. The skin, hair,…
Lupus Erythematosus
Abstract Lupus erythematosus is a multisystem disorder that prominently affects the skin. The most common types of cutaneous lupus are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid…
Calcifying and Ossifying Disorders of the Skin
Abstract Cutaneous deposition of calcium has a range of manifestations, from mild to fatal, and a number of etiologies. It is categorized as dystrophic if calcium deposits in pre-existing damaged…
Basic Principles of Genetics
Abstract Human disease can arise from genetic changes ranging from mutations in single nucleotides to alterations affecting entire chromosomes. Genetic skin diseases include Mendelian (monogenic) disorders caused by defects in…
Systemic Sclerosis (Scleroderma) and Related Disorders
Abstract Systemic sclerosis (SSc, scleroderma) is an uncommon autoimmune connective tissue disease of unknown etiology. The clinical hallmark of the disease is cutaneous sclerosis. Ninety-five percent of SSc patients present…
Amyloidosis
Abstract The cutaneous amyloidoses represent a heterogeneous group of conditions in which amyloid, a fibrillar material that can result from the degradation of various proteins, is deposited in the skin….
