Abstract Human survival depends on the ability to function effectively within a dry external environment. The epidermis functions as a barrier that maintains body hydration and excludes harmful external agents….
Abstract Interactions between or amongst multiple therapies may lead to increased toxicity, decreased efficacy, or both. Knowledge of the interactive properties of drugs can help prevent serious adverse drug interactions….
Abstract Systemic immunomodulators that are used to treat dermatologic disorders include interferons, intravenous immune globulin, and a variety of agents that target specific proteins (e.g. TNF, IL-17) involved in disease…
Abstract In addition to primary and secondary B- and T-cell lymphomas, there are benign lymphocytic infiltrates of the skin that can sometimes mimic cutaneous lymphomas. The latter include lymphocytic infiltrate…
Abstract Smooth muscle, adipose and cartilage neoplasms arising in the skin and subcutis comprise a wide spectrum of benign and malignant neoplasms that show myocyte, adipocyte, and chondrocyte differentiation, respectively….
Abstract Mastocytosis may occur at any age and results from mast cell proliferation, which can involve the skin, bone marrow, and other organs. Activating mutations in KIT have a pathogenic…
Abstract Cutaneous metastases are uncommon and in general are associated with a poor prognosis; rarely, they may be the presenting sign of an internal malignancy. Epidemiologic statistics are helpful in…
Abstract Skin conditions are a major cause of morbidity worldwide, representing the fourth most common source of nonfatal disease burden. Considering the high or increasing prevalence of many skin conditions,…
Abstract Benign cutaneous pigmented lesions may result from an increased production of melanin or a proliferation of melanocytes. In ephelides, café-au-lait macules (CALMs), Becker melanosis, and lentigines, there is an…
