Sarcoidosis
Key Points • Sarcoidosis is a multisystem granulomatous disease of unknown etiology that affects patients of all ages and ethnic groups. • Thorough multisystem evaluation of all patients is essential,…
Leg Ulcers
Abstract Leg ulcers are a frequent medical problem associated with considerable morbidity, increasing healthcare costs, and a decrease in the quality of life of patients. Approximately 70% of leg ulcers…
Cutaneous Drug Eruptions
Abstract Cutaneous drug reactions account for a large proportion of adverse drug reactions, can be very challenging to diagnose, and can mimic many other skin diseases. This chapter includes a…
Oral Disease
Abstract Pathologic changes of the oral mucous membranes involve the full gamut of systemic diseases ranging from genetic and autoimmune disorders, infections and neoplastic diseases, and the complications of our…
Nail Signs of Systemic Disease
Abstract Nail abnormalities may reveal signs of systemic diseases and often correlate to pathology in the nail matrix or nail bed. There are specific and nonspecific nail signs, which may…
Principles of Systemic Drug Use
Abstract Although the subject of systemic drug therapy for dermatologic conditions is vast, in this chapter we review the important principles that guide safe use. Supporting concepts and important clinical…
Hair Disorders in Systemic Disease
Abstract Systemic disease can bring about many changes in patients’ hair. Such changes include hair loss by various mechanisms, changes in hair texture, and excess hair growth. This chapter outlines…
Cutaneous Manifestations Observed in Transplant Recipients
Abstract Skin infections occur at a great frequency in solid organ and bone marrow transplant recipients largely as a consequence of immunosuppression. The presentation, evaluation, and management of the more…
Mast Cell Disease
Abstract Mastocytosis may arise in utero until later in life. Most patients with mastocytosis are children, but the true incidence of adult-onset disease is unknown. While the cause of this…
Neurocutaneous Disease
Abstract Neurocutaneous genetic disorders, also called phakomatoses, manifest with various cutaneous and neurologic findings. Examples include neurofibromatosis, tuberous sclerosis, Sturge–Weber syndrome, and von Hippel–Lindau syndrome, the first three of which…
