Topical Therapeutics

Feb 19, 2022 by in Dermatology Comments Off on Topical Therapeutics

Introduction Topical therapy is a mainstay of dermatological treatment and holds many advantages, including ease of use, relative lack of systemic side effects, and patient-directed application. In hidradenitis suppurativa (HS),…

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Genetics and Epigenetics of Hidradenitis Suppurativa

Feb 19, 2022 by in Dermatology Comments Off on Genetics and Epigenetics of Hidradenitis Suppurativa

Introduction Hidradenitis suppurativa (HS) is an inflammatory condition characterized by painful and sometimes purulent nodules, abscesses, and sinus tracts located in intertriginous regions. Lesions may progress to form hypertrophic scars…

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Follicular Occlusion and Inflammation

Feb 19, 2022 by in Dermatology Comments Off on Follicular Occlusion and Inflammation

Introduction The pathogenic model of hidradenitis suppurativa (HS) may be in the midst of a paradigm shift, balancing the initial model of a disorder of (primary) follicular occlusion with consideration…

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Microbiota Perturbations in Hidradenitis Suppurativa

Feb 19, 2022 by in Dermatology Comments Off on Microbiota Perturbations in Hidradenitis Suppurativa

Introduction Hidradenitis suppurativa (HS) is a disabling chronic inflammatory disease with significant comorbidities that affects an estimated 1% of the Western population. A poor understanding of HS biology has limited…

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Disease Complications

Feb 19, 2022 by in Dermatology Comments Off on Disease Complications

Introduction Over time, repeated episodes of hidradenitis suppurativa (HS) disease flares can lead to a number of debilitating cutaneous, systemic, as well as psychological and social complications. Given the progressive…

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Comorbidities and Systemic Associations

Feb 19, 2022 by in Dermatology Comments Off on Comorbidities and Systemic Associations

Introduction HS represents a prime candidate to bridge diseases of the integument and comorbid systemic disease, as a chronic inflammatory disease of the pilosebaceous unit characterized by inflammatory nodules, suppuration…

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Clinical Evaluation

Feb 19, 2022 by in Dermatology Comments Off on Clinical Evaluation

Overview of Patient Population with HS Prior to Initiating Therapy Hidradenitis suppurativa is a clinical diagnosis based on history, physical exams, patterns of recurrence, types of lesions, and scarring. No…

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