Background
Definitions Gender Dysphoria The term gender dysphoria describes a heterogeneous group of individuals who express varying degrees of discomfort with or disassociation from their anatomic gender. Some people with this…
General Surgery
Ixekizumab
Keywords Ixekizumab, Taltz, Interleukin-17A, Monoclonal antibody, UNCOVER-2, UNCOVER-3 Key points • Ixekizumab is a humanized monoclonal antibody against interleukin-17A. • Ixekizumab is more efficacious in the treatment of plaque…
Investigational Therapies for Psoriasis
Keywords Janus kinase, Tumor necrosis factor-α, Interleukin-17, Interleukin-23 Key points • Investigational therapies aim to inhibit the specific immunologic mechanisms behind plaque psoriasis without widely affecting the normal immune…
Biosimilars
Keywords Biosimilar, Inflectra, Remsima, CT-P13, Infliximab-dyyb Key points • Through the Biologics Price Competition and Innovation act, the US Food and Drug Administration (FDA) has defined a biosimilar as…
Combination Therapies for Psoriasis
Keywords Psoriasis, Combination, Acitretin, Cyclosporine, Methotrexate, Biologics, Etanercept, Adalimumab Key points • Combination therapies of biologics and systemic agents for psoriasis treatment can potentially enhance efficacy of treatment, increase…
Secukinumab
Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…
Adalimumab
Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…
Ustekinumab
Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…
Etanercept
Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…
Apremilast
Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…
