Informed Consent: Protecting the Patient and the Surgeon
The Process of Informed Consent Neal R. Reisman MD, JD, FACS The process of informed consent is very important to the practice of plastic surgery. Not only is it a…
Plectin Gene Defects Lead to Various Forms of Epidermolysis Bullosa Simplex
Plectin is an important organizer of the keratin filament cytoskeleton in basal keratinocytes. It is essential for anchoring these filaments to the extracellular matrix via hemidesmosomal integrins. Loss of plectin…
Quality of Life Measurements in Epidermolysis Bullosa: Tools for Clinical Research and Patient Care
Quality of life (QOL) evaluation in epidermolysis bullosa (EB) has important applications in clinical management, patient advocacy, clinical research, and the development of new treatments. Several new quantitative and qualitative…
Epidermolysis Bullosa Nevi
Epidermolysis bullosa (EB) nevi are large, eruptive, asymmetrical, often irregularly pigmented melanocytic lesions. Such nevi may give rise to small satellite nevi surrounding the primary nevus, and thus frequently manifest…
Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma
Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize…
Alopecia in Epidermolysis Bullosa
Hair abnormalities observed in epidermolysis bullosa (EB) are of variable severity and include mild hair shaft abnormalities, patchy cicatricial alopecia, cicatricial alopecia with a male pattern distribution, and alopecia universalis….
Nail Involvement in Epidermolysis Bullosa
Nail abnormalities are a common feature in most subtypes of epidermolysis bullosa (EB), and they recently have been included among the criteria for scoring EB severity. Trauma undoubtedly contributes to…
Oral Manifestations in the Epidermolysis Bullosa Spectrum
The craniofacial and oral manifestations of the different epidermolysis bullosa (EB) types vary markedly in character and severity depending largely on the EB type. The tissues affected and the phenotypes…
Ophthalmic Involvement in Inherited Epidermolysis Bullosa
Eye involvement in inherited epidermolysis bullosa (EB) can occur as a spectrum of symptoms and signs. This article describes these signs and symptoms. It also offers options for treatment. Eye…
Animal Models of Epidermolysis Bullosa
For more than 2 decades, animal models have been used to clarify the pathogenic mechanisms of human diseases and develop new therapeutics for these diseases. Several therapies for human diseases…
