Fungal Diseases
Abstract Cutaneous fungal infections with systemic involvement can be divided clinically into subcutaneous mycoses and systemic mycoses, based on mode of acquisition and the extent of tissue involvement. Subcutaneous mycoses…
Protozoal Diseases
Abstract Protozoan organisms continue to represent a major disease burden worldwide. Diseases such as toxoplasmosis affect much of the population, and other diseases like leishmaniasis have undergone a resurgence in…
Bacterial and Rickettsial Diseases
Abstract Cutaneous bacterial infections are important causes of morbidity. Meticillin-resistant staphylococcal infections present as abscess or folliculitis, and drainage remains the key component of management. Lyme disease presents with annular…
Hepatic Disease and the Skin
Abstract There are numerous cutaneous manifestations of liver disease. This chapter focuses on the most common cutaneous manifestations of hepatic disease including diagnosis, management, and therapy. KeywordsCryoglobulins, Hemochromatosis, Hepatic, Hepatitis,…
Viral Diseases
Abstract Viruses produce a variety of cutaneous changes, including morbilliform (measles-like), papular, and vesicular eruptions. It is often difficult to distinguish viral exanthems from morbilliform drug eruptions; however, subtle distinguishing…
Cutaneous Diseases Associated with Gastrointestinal Abnormalities
Abstract Gastrointestinal diseases have many cutaneous associations. Gastrointestinal hemorrhage may be associated with the peau d’orange plaques of pseudoxanthoma elasticum or the macular telangiectases of hereditary hemorrhagic telangiectasia. Adenomatous polyposis…
Vascular Neoplasms and Malformations
Abstract A variety of vascular lesions can serve as cutaneous signs of systemic disease. Although telangiectasias are common, they occasionally represent markers for autoimmune connective tissue diseases and genetic conditions…
Porphyrias
Abstract Porphyrias are a group of inherited or acquired metabolic disorders manifested by cutaneous photosensitivity, episodic neurovisceral dysfunctions, or both. Each porphyria is caused by reduced activity (or in one…
Cutaneous Manifestations of Lipid Disorders
Abstract Cutaneous xanthomas may signal an underlying lipid, metabolic, or hematologic abnormality, so accurate diagnosis is essential. The clinical presentations of different types of xanthomas including eruptive, tuberous, planar, and…
Adrenal, Androgen-Related, and Pituitary Disorders
Key Points • Classic signs of excess cortisol (Cushing’s) include moon facies, striae, atrophy, and acne. • Cortisol deficiency (Addison’s) presents with hyperpigmentation of the skin, nails, and mucous membranes….
