Non-Antibiotic and Non-Biologic Systemic Therapeutics

Feb 19, 2022 by in Dermatology Comments Off on Non-Antibiotic and Non-Biologic Systemic Therapeutics

Introduction The pathogenesis of hidradenitis suppurativa (HS) remains to be fully elucidated. Genetic susceptibility along with hormonal fluctuations and immune dysregulation are all thought to contribute to HS development. HS…

read more

Targeted Therapeutics: Biologics, Small Molecules

Feb 19, 2022 by in Dermatology Comments Off on Targeted Therapeutics: Biologics, Small Molecules

Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory disorder with a complex, multifactorial, and incompletely elucidated pathophysiology. Among relevant host factors are a number of important inflammatory pathways, including increased…

read more

Systemic Antibiotics in Hidradenitis Suppurativa

Feb 19, 2022 by in Dermatology Comments Off on Systemic Antibiotics in Hidradenitis Suppurativa

Introduction Antibiotics alone, or in combination with other therapeutic strategies, have been empirically used in hidradenitis suppurativa (HS) with variable success, resulting only in temporary symptom relief in the disease…

read more

Disease Evaluation and Outcome Measures

Feb 19, 2022 by in Dermatology Comments Off on Disease Evaluation and Outcome Measures

Introduction Outcome measures play an important role in the field of dermatology, both in routine clinical practice and in clinical research trials. In clinical settings, robust outcome measures serve to…

read more

Topical Therapeutics

Feb 19, 2022 by in Dermatology Comments Off on Topical Therapeutics

Introduction Topical therapy is a mainstay of dermatological treatment and holds many advantages, including ease of use, relative lack of systemic side effects, and patient-directed application. In hidradenitis suppurativa (HS),…

read more

Genetics and Epigenetics of Hidradenitis Suppurativa

Feb 19, 2022 by in Dermatology Comments Off on Genetics and Epigenetics of Hidradenitis Suppurativa

Introduction Hidradenitis suppurativa (HS) is an inflammatory condition characterized by painful and sometimes purulent nodules, abscesses, and sinus tracts located in intertriginous regions. Lesions may progress to form hypertrophic scars…

read more

Follicular Occlusion and Inflammation

Feb 19, 2022 by in Dermatology Comments Off on Follicular Occlusion and Inflammation

Introduction The pathogenic model of hidradenitis suppurativa (HS) may be in the midst of a paradigm shift, balancing the initial model of a disorder of (primary) follicular occlusion with consideration…

read more

Microbiota Perturbations in Hidradenitis Suppurativa

Feb 19, 2022 by in Dermatology Comments Off on Microbiota Perturbations in Hidradenitis Suppurativa

Introduction Hidradenitis suppurativa (HS) is a disabling chronic inflammatory disease with significant comorbidities that affects an estimated 1% of the Western population. A poor understanding of HS biology has limited…

read more
Get Clinical Tree app for offline access