Abstract This chapter focuses on key events and regulatory mechanisms that result in the morphogenesis, maintenance, and regeneration of the skin and its appendages. Understanding skin development provides essential insights…
Key Points • Sarcoidosis is a multisystem granulomatous disease of unknown etiology that affects patients of all ages and ethnic groups. • Thorough multisystem evaluation of all patients is essential,…
Abstract Leg ulcers are a frequent medical problem associated with considerable morbidity, increasing healthcare costs, and a decrease in the quality of life of patients. Approximately 70% of leg ulcers…
Abstract Cutaneous drug reactions account for a large proportion of adverse drug reactions, can be very challenging to diagnose, and can mimic many other skin diseases. This chapter includes a…
Abstract Pathologic changes of the oral mucous membranes involve the full gamut of systemic diseases ranging from genetic and autoimmune disorders, infections and neoplastic diseases, and the complications of our…
Abstract Nail abnormalities may reveal signs of systemic diseases and often correlate to pathology in the nail matrix or nail bed. There are specific and nonspecific nail signs, which may…
Abstract Although the subject of systemic drug therapy for dermatologic conditions is vast, in this chapter we review the important principles that guide safe use. Supporting concepts and important clinical…
Abstract Systemic disease can bring about many changes in patients’ hair. Such changes include hair loss by various mechanisms, changes in hair texture, and excess hair growth. This chapter outlines…
Abstract Skin infections occur at a great frequency in solid organ and bone marrow transplant recipients largely as a consequence of immunosuppression. The presentation, evaluation, and management of the more…
Abstract Mastocytosis may arise in utero until later in life. Most patients with mastocytosis are children, but the true incidence of adult-onset disease is unknown. While the cause of this…
