Mohs Surgery for Squamous Cell Carcinoma
Cutaneous squamous cell carcinoma (SCC) is the second most common human cancer and can behave aggressively. Mohs micrographic surgery offers the highest cure rates for high-risk SCCs and is particularly…
Mohs Micrographic Surgery Technique
This article provides a protocol for the systematic approach to the technique of Mohs micrographic surgery. Each step, from tumor excision and tissue mapping, to specimen processing and histologic interpretation,…
History of Mohs Surgery
Mohs micrographic surgery (MMS) has become the gold standard for treating many forms of primary and recurrent contiguous skin cancers and offers the highest cure rates and maximum tissue conservation…
Clinical Features, Diagnosis, and Pathogenesis of Chronic Bullous Disease of Childhood
Chronic bullous disease of childhood (CBDC) is the most common acquired autoimmune blistering disorder of childhood and is characterized by linear IgA staining of the basement membrane zone on direct…
Pemphigus and Quality of Life
Measuring the impact of disease on quality of life (QOL) is important for evaluating effectiveness of care and capturing aspects of health that may not correlate with clinical severity. Few…
Objective Scoring Systems for Disease Activity in Autoimmune Bullous Disease
Objectively evaluating disease activity in autoimmune bullous disease (AIBD) is important in terms of the clinical assessment of patients and as an outcome measure for clinical trials. Measures need to…
Nail Involvement in Autoimmune Bullous Disorders
Autoimmune bullous disorders frequently cause nail abnormalities, particularly paronychia and onychomadesis. In pemphigus vulgaris (PV) nail abnormalities can even precede skin findings. Nail lesions often relapse just before generalized disease…
Pathogenesis of Epidermolysis Bullosa Acquisita
Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies to type VII collagen. Clinically, a noninflammatory and an inflammatory variant of EBA can be distinguished. Despite…
Hair Loss in Autoimmune Cutaneous Bullous Disorders
The expression of the basement membrane zone (BMZ) components in the anagen hair follicles of the human scalp is similar to that of interfollicular epidermis. Expression of the BMZ components…
Diagnosis and Clinical Features of Epidermolysis Bullosa Acquisita
Epidermolysis bullosa acquisita (EBA) is a rare autoimmune subepidermal blistering disease characterized by immune deposits on anchoring fibrils of cutaneous and mucosal basement membrane zones. It is due to circulating…
