Abstract Cutaneous disorders associated with malignancy are classified as: (1) those that fit Curth’s postulates and thus warrant specific investigation; (2) those that are statistically related to internal malignancy but…
Abstract Metastatic disease to the skin is not uncommon. Skin metastases may be the first sign of an internal malignancy and may offer the most accessible site for diagnosis. In…
Abstract Immunobullous diseases, while rare, may present severe medical and therapeutic challenges to the treating clinician. These entities include pemphigus and its variants, bullous pemphigoid and its variants, epidermolysis bullosa…
Abstract Erythroderma is defined as erythema covering more than 90% of the body and can present with or without scale. Although many cases are idiopathic, investigation of underlying causes is…
Abstract Erythema multiforme (EM), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are immunologically mediated, mucocutaneous reactions triggered by medications and infections. Clinical presentation ranges from targetoid lesions in EM…
Abstract The panniculitides are a group of heterogeneous inflammatory diseases involving the subcutaneous fat. The clinical findings are often insufficient for establishing diagnosis, and a biopsy is usually necessary to…
Abstract Eosinophil-associated diseases are a spectrum of disorders in which eosinophils play a central role in the pathophysiology. Clinical manifestations result from activated eosinophils in tissues and/or from eosinophil-derived factors…
