Abstract A variety of vascular lesions can serve as cutaneous signs of systemic disease. Although telangiectasias are common, they occasionally represent markers for autoimmune connective tissue diseases and genetic conditions…
Abstract Porphyrias are a group of inherited or acquired metabolic disorders manifested by cutaneous photosensitivity, episodic neurovisceral dysfunctions, or both. Each porphyria is caused by reduced activity (or in one…
Abstract Cutaneous xanthomas may signal an underlying lipid, metabolic, or hematologic abnormality, so accurate diagnosis is essential. The clinical presentations of different types of xanthomas including eruptive, tuberous, planar, and…
Key Points • Classic signs of excess cortisol (Cushing’s) include moon facies, striae, atrophy, and acne. • Cortisol deficiency (Addison’s) presents with hyperpigmentation of the skin, nails, and mucous membranes….
Abstract When evaluating cysts and nodules of the head and neck, consider thyroglossal ductal cysts and thyroid carcinoma metastases. There are many syndromes associated with thyroid cancer with dermatologic manifestations…
Abstract Diabetes mellitus is a common chronic disease that is associated with cutaneous manifestations in up to 70% of patients at some point of the disease. Cutaneous manifestations of diabetes…
Abstract Many diseases with cutaneous manifestations are also associated with monoclonal gammopathies. Monoclonal gammopathies are often idiopathic and increase in incidence with age and by ethnicity: African-American > Caucasian >…
Abstract This chapter discusses the unique group of disorders known as the histiocytoses, with an emphasis on Langerhans cell histiocytosis (LCH). Both LCH and the group of disorders comprising non-Langerhans…
Abstract Over the last few decades, treatment of cancer has evolved to include therapies that may be broadly categorized as traditional cytotoxic chemotherapies, hormonal therapies, targeted therapies, and immunotherapies. From…
Abstract Malignant lymphomas may affect the skin both primarily (i.e., without extracutaneous disease at presentation) and secondarily (i.e., as specific manifestations of a primary extracutaneous—usually nodal—lymphoma). Differentiation of primary from…
