Pathogenesis of Bullous Pemphigoid

Feb 12, 2018 by in Dermatology Comments Off on Pathogenesis of Bullous Pemphigoid

Bullous pemphigoid, the most common autoimmune blistering disease, is induced by autoantibodies against type XVII collagen. Passive transfer of IgG or IgE antibodies against type XVII collagen into animals has…

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Pemphigoid Gestationis: Pathogenesis and Clinical Features

Feb 12, 2018 by in Dermatology Comments Off on Pemphigoid Gestationis: Pathogenesis and Clinical Features

Pemphigoid gestationis is a rare, autoimmune bullous disease of pregnancy that involves autoantibodies directed against type XVII collagen in the basement membrane zone. This article discusses the immunopathogenesis, diagnostic methods,…

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Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome): Clinical Presentations and Pathogenesis

Feb 12, 2018 by in Dermatology Comments Off on Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome): Clinical Presentations and Pathogenesis

Paraneoplastic pemphigus is a rare condition with extremely high rates of mortality. Although its pathogenesis is incompletely understood, its pathologic findings have significant overlap with other autoimmune blistering diseases, such…

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Pathogenesis of Endemic Pemphigus Foliaceus

Feb 12, 2018 by in Dermatology Comments Off on Pathogenesis of Endemic Pemphigus Foliaceus

Pemphigus refers to a group of human autoimmune blistering diseases involving skin and/or mucous membranes. Endemic pemphigus foliaceus (EPF), or fogo selvagem is an organ-specific autoimmune blistering disease, first reported…

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A Globally Available Internet-Based Patient Survey of Pemphigus Vulgaris: Epidemiology and Disease Characteristics

Feb 12, 2018 by in Dermatology Comments Off on A Globally Available Internet-Based Patient Survey of Pemphigus Vulgaris: Epidemiology and Disease Characteristics

The authors developed an anonymous, Web-based survey instrument available globally, and collected data from 171 pemphigus vulgaris (PV) patients to assemble epidemiologic data pertaining to an extensive set of clinical…

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Diagnosis and Clinical Features of Pemphigus Foliaceus

Feb 12, 2018 by in Dermatology Comments Off on Diagnosis and Clinical Features of Pemphigus Foliaceus

Pemphigus foliaceus is an acquired autoimmune blistering disease in which the body’s immune system produces IgG autoantibodies that target the intercellular adhesion glycoprotein desmoglein-1, which is principally expressed in the…

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The Genetics of Pemphigus

Feb 12, 2018 by in Dermatology Comments Off on The Genetics of Pemphigus

Pemphigus vulgaris (PV) is an autoimmune blistering disorder with a complex etiology involving an interplay of genetic as well as environmental factors, most of which remain unknown. Despite the identification…

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Diagnosis and Clinical Features of Pemphigus Vulgaris

Feb 12, 2018 by in Dermatology Comments Off on Diagnosis and Clinical Features of Pemphigus Vulgaris

Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at…

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