Keywords Janus kinase, Tumor necrosis factor-α, Interleukin-17, Interleukin-23 Key points • Investigational therapies aim to inhibit the specific immunologic mechanisms behind plaque psoriasis without widely affecting the normal immune…
Keywords Biosimilar, Inflectra, Remsima, CT-P13, Infliximab-dyyb Key points • Through the Biologics Price Competition and Innovation act, the US Food and Drug Administration (FDA) has defined a biosimilar as…
Keywords Psoriasis, Combination, Acitretin, Cyclosporine, Methotrexate, Biologics, Etanercept, Adalimumab Key points • Combination therapies of biologics and systemic agents for psoriasis treatment can potentially enhance efficacy of treatment, increase…
Keywords Secukinumab, Cosentyx, Interleukin-17A, Monoclonal antibody, ERASURE, FIXTURE, JUNCTURE, FEATURE Key points • Secukinumab is a first-in-class human monoclonal antibody against interleukin-17A. • Secukinumab has been demonstrated in clinical…
Keywords Adalimumab, TNF-α, Psoriasis, CHAMPION, REVEAL, ADEPT, ESPRIT Key points • Adalimumab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of action…
Keywords Ustekinumab, Stelara, Psoriasis, Interleukin-12, Interleukin-23, PASI Key points • Ustekinumab is a human immunoglobulin G κ monoclonal antibody that binds to the p40 protein subunit shared by interleukin-12…
Keywords Etanercept, Enbrel, TNF-α, OBSERVE-5, Biologic Key points • Etanercept is a soluble human dimeric fusion protein that competitively binds and inhibits tumor necrosis factor. • Etanercept improved psoriatic…
Keywords Apremilast, Plaque psoriasis, Phosphodiesterase 4, Psoriatic arthritis Key points • Apremilast is the first small molecule phosphodiesterase 4 (PDE4) inhibitor approved for treatment of moderate-to-severe plaque psoriasis. •…
Keywords Infliximab, TNF-α, Psoriasis, SPIRIT, EXPRESS, EXPRESS II, IMPACT Key points • Infliximab is a safe and effective therapy for the treatment of moderate-to-severe psoriasis. • The mechanism of…
Keywords Cyclosporine, CsA, Neoral, Sandimmune, PISCES, PREWENT Key points • Cyclosporine (CsA) is a highly effective treatment option for patients with moderate-to-severe plaque psoriasis with a rapid onset of…
