Erythroderma
Abstract Erythroderma is defined as erythema covering more than 90% of the body and can present with or without scale. Although many cases are idiopathic, investigation of underlying causes is…
Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis
Abstract Erythema multiforme (EM), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are immunologically mediated, mucocutaneous reactions triggered by medications and infections. Clinical presentation ranges from targetoid lesions in EM…
Panniculitis
Abstract The panniculitides are a group of heterogeneous inflammatory diseases involving the subcutaneous fat. The clinical findings are often insufficient for establishing diagnosis, and a biopsy is usually necessary to…
Eosinophil-Associated Diseases with Dermatologic Manifestations
Abstract Eosinophil-associated diseases are a spectrum of disorders in which eosinophils play a central role in the pathophysiology. Clinical manifestations result from activated eosinophils in tissues and/or from eosinophil-derived factors…
Neutrophilic Dermatoses
Abstract Neutrophilic dermatoses comprise a spectrum of skin diseases with various cutaneous manifestations and a predominantly neutrophilic infiltrate on histopathology. Neutrophilic dermatoses are associated with a variety of systemic diseases…
Autoinflammatory Syndromes
Abstract Autoinflammatory syndromes are a recently described group of disorders characterized by inflammation mediated by the innate immune system. All these syndromes have cutaneous presentations in addition to multiorgan involvement….
Other Rheumatologic–Dermatologic Conditions
Abstract Cutaneous findings are commonly observed in rheumatologic conditions. These skin findings occur in association with underlying rheumatologic disease and are variably associated with disease state activity. In this chapter…
Scleroderma, Raynaud’s Phenomenon, and Related Conditions
Abstract The clinical differential diagnosis of “hard skin” can be divided into two main diagnostic categories: morphea and morphea-like conditions and systemic sclerosis and sclerodermoid conditions. Patients with morphea and…
