Abstract Erythema multiforme (EM), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are immunologically mediated, mucocutaneous reactions triggered by medications and infections. Clinical presentation ranges from targetoid lesions in EM…
Abstract The panniculitides are a group of heterogeneous inflammatory diseases involving the subcutaneous fat. The clinical findings are often insufficient for establishing diagnosis, and a biopsy is usually necessary to…
Abstract Eosinophil-associated diseases are a spectrum of disorders in which eosinophils play a central role in the pathophysiology. Clinical manifestations result from activated eosinophils in tissues and/or from eosinophil-derived factors…
Abstract Neutrophilic dermatoses comprise a spectrum of skin diseases with various cutaneous manifestations and a predominantly neutrophilic infiltrate on histopathology. Neutrophilic dermatoses are associated with a variety of systemic diseases…
Abstract Autoinflammatory syndromes are a recently described group of disorders characterized by inflammation mediated by the innate immune system. All these syndromes have cutaneous presentations in addition to multiorgan involvement….
Abstract Cutaneous findings are commonly observed in rheumatologic conditions. These skin findings occur in association with underlying rheumatologic disease and are variably associated with disease state activity. In this chapter…
Abstract The clinical differential diagnosis of “hard skin” can be divided into two main diagnostic categories: morphea and morphea-like conditions and systemic sclerosis and sclerodermoid conditions. Patients with morphea and…
Abstract Vasculitis includes a heterogeneous group of conditions characterized by blood vessel inflammation and necrosis. The clinical manifestations depend on the localization and size of the involved vessel. Most patients…
