Abstract Diabetes mellitus is a common chronic disease that is associated with cutaneous manifestations in up to 70% of patients at some point of the disease. Cutaneous manifestations of diabetes…

Abstract Many diseases with cutaneous manifestations are also associated with monoclonal gammopathies. Monoclonal gammopathies are often idiopathic and increase in incidence with age and by ethnicity: African-American > Caucasian >…

Abstract This chapter discusses the unique group of disorders known as the histiocytoses, with an emphasis on Langerhans cell histiocytosis (LCH). Both LCH and the group of disorders comprising non-Langerhans…

Abstract Over the last few decades, treatment of cancer has evolved to include therapies that may be broadly categorized as traditional cytotoxic chemotherapies, hormonal therapies, targeted therapies, and immunotherapies. From…

Abstract Malignant lymphomas may affect the skin both primarily (i.e., without extracutaneous disease at presentation) and secondarily (i.e., as specific manifestations of a primary extracutaneous—usually nodal—lymphoma). Differentiation of primary from…

Abstract Cutaneous disorders associated with malignancy are classified as: (1) those that fit Curth’s postulates and thus warrant specific investigation; (2) those that are statistically related to internal malignancy but…

Abstract Metastatic disease to the skin is not uncommon. Skin metastases may be the first sign of an internal malignancy and may offer the most accessible site for diagnosis. In…

Abstract Immunobullous diseases, while rare, may present severe medical and therapeutic challenges to the treating clinician. These entities include pemphigus and its variants, bullous pemphigoid and its variants, epidermolysis bullosa…

Abstract Purpura is an important physical finding, both for serious and incidental disease. The ability to rapidly sort through diagnostic possibilities depends on recognition of morphologic subsets of purpura, and…

Abstract Erythroderma is defined as erythema covering more than 90% of the body and can present with or without scale. Although many cases are idiopathic, investigation of underlying causes is…