Abstract Pathologic changes of the oral mucous membranes involve the full gamut of systemic diseases ranging from genetic and autoimmune disorders, infections and neoplastic diseases, and the complications of our…

Abstract Nail abnormalities may reveal signs of systemic diseases and often correlate to pathology in the nail matrix or nail bed. There are specific and nonspecific nail signs, which may…

Abstract Systemic disease can bring about many changes in patients’ hair. Such changes include hair loss by various mechanisms, changes in hair texture, and excess hair growth. This chapter outlines…

Abstract Skin infections occur at a great frequency in solid organ and bone marrow transplant recipients largely as a consequence of immunosuppression. The presentation, evaluation, and management of the more…

Abstract Mastocytosis may arise in utero until later in life. Most patients with mastocytosis are children, but the true incidence of adult-onset disease is unknown. While the cause of this…

Abstract Neurocutaneous genetic disorders, also called phakomatoses, manifest with various cutaneous and neurologic findings. Examples include neurofibromatosis, tuberous sclerosis, Sturge–Weber syndrome, and von Hippel–Lindau syndrome, the first three of which…

Abstract Chronic kidney disease (CKD) has numerous deleterious systemic effects including impaired function of the heart, brain, and nervous system, altered hormonal balance and bone metabolism, and a decreased ability…

Abstract Myriad cutaneous changes, both physiologic and pathologic, occur in the context of pregnancy. Pregnancy-related alterations of the skin may be classified as: (1) physiologic changes; (2) changes to cutaneous…

Abstract Human immunodeficiency syndrome (HIV) infection can be related to the development of a variety of skin diseases, and dermatologic diagnoses in HIV patients may be a reflection of their…