Syndrome Gene mutation and inheritance Clinical features RMS type and/or features Other associated malignancies Li–Fraumeni P53 AD Early onset malignancy, familial Anaplastic RMS presents in children <3 years old • Breast…
Fig. 11.1 Basal cell carcinoma on the nose of a teenage heart transplant recipient (image courtesy of Susan J. Bayliss, MD) Voriconazole , a triazole antifungal , is effective at…
Fig. 5.1 Numerous small skin-colored, dome-shaped papules on the neck, consistent with early basal cell carcinomas in Gorlin syndrome Fig. 5.2 Palmar pits , which can be subtle clinically but…
Fig. 10.1 Widespread cutaneous methicillin-sensitive Staphylococcus aureus infection in a renal transplant recipient (image courtesy of Carrie C. Coughlin, MD) Cellulitis is a superficial infection of the dermis and/or subcutaneous…
Fig. 1.1 Characteristic appearance of a Spitz nevus as a smooth dome-shaped pink papule [16]. Reprinted from Journal of the American Academy of Dermatology, Vol. 65, No. 6, Luo S,…
Classification Percent of pediatric cases (%) Description Associated signs and symptoms Prognosis Cutaneous solitary mastocytoma 20 Solitary macule or plaque with mast cell infiltrate Itching, lymphadenopathy Excellent: >90% show partial…
Fig. 17.1 Intractable erythema of the face: erythema of the face is a common manifestation in adult (adolescence/adulthood) phase. It is characterized by edematous erythema and many papules and is…
Fig. 11.1 Differential localization of sweat pores of eccrine glands in relation to skin folds and ridges. (a) In glabrous skin, such as fingertips, sweat pores open at the ridges…
Fig. 14.1 Pathomechanisms of atopic dermatitis. Environmental allergens trigger the overproduction of IgE antibody when they come in through barrier-disrupted sensitive, atopic skin, while chemical or bacterial factors induce epidermal…
Major features • Pruritus • Facial and extensor eczema in infants and children • Flexural eczema in adolescents • Chronic or relapsing dermatitis • Personal or history of atopic disease…
