Plastic Surgery Key

Abstract The porphyrias comprise a clinically and genetically heterogeneous group of diseases mostly arising from a genetically determined dysfunction of specific enzymes in the heme biosynthetic pathway. Based on the…

Abstract Lupus erythematosus is a multisystem disorder that prominently affects the skin. The most common types of cutaneous lupus are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid…

Abstract Cutaneous deposition of calcium has a range of manifestations, from mild to fatal, and a number of etiologies. It is categorized as dystrophic if calcium deposits in pre-existing damaged…

Abstract Human disease can arise from genetic changes ranging from mutations in single nucleotides to alterations affecting entire chromosomes. Genetic skin diseases include Mendelian (monogenic) disorders caused by defects in…

Abstract Systemic sclerosis (SSc, scleroderma) is an uncommon autoimmune connective tissue disease of unknown etiology. The clinical hallmark of the disease is cutaneous sclerosis. Ninety-five percent of SSc patients present…

Abstract The cutaneous amyloidoses represent a heterogeneous group of conditions in which amyloid, a fibrillar material that can result from the degradation of various proteins, is deposited in the skin….

Abstract The cutaneous mucinoses are a heterogeneous group of disorders characterized by an abnormal accumulation of mucin within the skin. While the precise pathogenesis is unknown, cytokines (e.g. TNF, interleukin-1,…

Abstract The clinicopathologic features of the following entities are reviewed: systemic-onset juvenile idiopathic arthritis (sJIA), adult-onset Still disease, relapsing polychondritis, Sjögren syndrome, mixed connective tissue disease (MCTD), and rheumatoid arthritis,…

Abstract The cutaneous deposition disorders are a heterogeneous group of conditions characterized by the presence of primarily endogenous substances within the dermis and/or the subcutis. These include gout, pseudogout, lipoid…

Abstract Dermatomyositis is an autoimmune disease that most often affects both the muscles and the skin (classic dermatomyositis), but also may occur in a skin-predominant fashion (clinically amyopathic dermatomyositis). All…