New and Future Therapies
Fig. 26.1 Partial cellular and molecular immunological mechanisms in lesional skin of AD. Factors surrounded by red square are targets of therapeutic approaches described in this manuscript. ‘Acute’ shows acute…
Approach for Aggravating Factors in Atopic Dermatitis
Fig. 24.1 Causes and exacerbating factors. Since causes and exacerbating factors vary among patients, care should be taken to identify them sufficiently for each patient before taking removal measures. Modified…
History and Definition
Diagnostic term Author Mycosis sive eczema flexurarum Hebra (1884) Lichen simplex chronicus disseminatus Vidal (1886) Neurodermite disseminatus Brocq and Jacquet (1891) Prurigo diathetique eczemato-lichenienne Besnier (1892) Neurodermite diffuse Brocq (1902)…
Impairment of Productivity in the Workplace/Classroom in Japanese Patients with Atopic Dermatitis
Fig. 25.1 Conceptual illustration of “absenteeism” and “presenteeism” There are several assessment procedures for measuring patients’ work productivity. Those procedures share core assessment domains with each other. The major shared…
Skin Care and Intervention
Fig. 23.1 Proportions of infants who did not have AD/eczema. Kaplan-Meier plots show the proportions of infants in the intervention (circle) and control (triangle) groups with AD/eczema during the first…
Extrinsic and Intrinsic Atopic Dermatitis
Fig. 15.1 AD spectrum encompassing extrinsic and intrinsic AD. AD can be divided into barrier-disrupted, high-IgE extrinsic type and barrier-preserved, normal-IgE intrinsic type. Some of the patients with extrinsic AD…
Psychological Stress in Atopic Dermatitis
Fig. 13.1 Cohort questionnaire study of Osaka University students with AD (n = 288) who were followed for 4 years from 2012 to 2016 Fig. 13.2 The change in patient…
Microbiome, Dysbiosis, and Atopic Dermatitis
Fig. 12.1 Homeostasis of physiological skin barrier and S. aureus-derived virulence factors. KLK kallikrein, LEKTI lymphoepithelial Kazal-type-related inhibitor, NMF natural moisturizing factor, SCCE stratum corneum chymotryptic enzyme, SCTE stratum corneum…
Genome-Wide Association Study for Atopic Dermatitis in the Japanese Population
Chromosome Locus Population Reference 11q13.5 C11ORF30/LRRC32 (GARP) European [5] 1p21.3 FLG Chinese Han [6] 5q22.1 TMEM232/SLC25A46 20q13.33 TNFRSF6B/ZGPAT 11q13.1 OVOL1 European [9] 19p13.2 ACTL9 5q31.1 KIF3A/RAD50/IL13 …
Food Allergy
Organ Symptoms Skin Erythema, urticaria, angioedema, pruritus, burning, sensation, eczema Mucous membrane Eye symptoms: Conjunctival hyperemia and edema, pruritus, lacrination, blepharedema Nasal symptoms: Rhinorrhea, nasal congestion, sneezing Oral symptoms: Discomfort/swelling…
