Skin and Gut Microbiome
Key points • The human microbiome consists of a wide variety of microorganisms that assist in key physiologic processes. • The majority of microbial diversity is found on the skin…
Skin Barrier
Key points • The four layers of the epidermis—stratum corneum, stratum granulosum, stratum spinosum, and stratum basale—are composed of keratinocytes, which undergo differentiation and mature as they become more superficial…
Epidemiology
Key points • Atopic dermatitis is one of the most common inflammatory diseases of the skin, with both genetic and environmental etiologies. • The prevalence of atopic dermatitis is increasing…
Atopy Redefined
Key points • Although the original term atopy provides a general framework of understanding about allergic clinical conditions, this big umbrella now includes a group of patients who have heterogeneous…
Historic Perspective
Key points • From the historic perspective, atopic dermatitis has gone through several evolutionary periods of understanding and development. • From ancient times to the 18th century, medical communities started…
