Organ or site Diagnostic (sufficient to establish the diagnosis of chronic GVHD) Distinctive (seen in chronic GVHD, but insufficient alone to establish a diagnosis) Other features or unclassified entities Skin…

Host variables  Recipient age <1 or >10 years [10]  Malignancy as indication for transplant, as well as features of more advanced disease (WBC >50 × 109/L and cytogenetic abnormalities t(4;11),…

Common manifestations Atypical manifestations aGVHD cGVHDa aGVHD cGVHD Maculopapular rash Poikiloderma Eczematous eruptions (contact dermatitis [2], eczema craquele [3]) Eczematous eruptions [4, 5] (atopic dermatitis [6], eczema craquele [7], and…

Fig. 3.1 Erythema of the face with accentuation of the ear Fig. 3.2 Erythema of the ear Fig. 3.3 Palmar erythema Fig. 3.4 Palmar erythema (Note microvesicles that herald edema.)…

  Lerner grading system [11] Horn grading system [7] Grade 0  Normal skin or unrelated cutaneous disease Grade 1 Vacuolar alteration Vacuolar alteration Grade 2 Spongiosis and dyskeratosis (eosinophilic bodies)…

Fig. 10.1 Poikilodermic cGVHD on the neck and upper chest Fig. 10.2 Lichen planus–like chronic graft-versus-host disease (cGVHD). (a) Woman with lichen planus–like cGVHD on the face. (b) Man with…

Fig. 8.1 Shiny, hypopigmented plaques with satellite plaques over the gluteal fold, representing superficial dermal chronic graft-versus-host disease (cGVHD) of the lichen sclerosus type Deep Dermis: Morpheaform Type The classic…

Fig. 4.1 Ocular graft-versus-host disease. Ocular GVHD can affect almost every structure of the eye. Distinctive characteristics of chronic ocular GVHD include keratoconjunctivitis sicca, confluent areas of punctate keratopathy, and…