Fig. 15.1 AD spectrum encompassing extrinsic and intrinsic AD. AD can be divided into barrier-disrupted, high-IgE extrinsic type and barrier-preserved, normal-IgE intrinsic type. Some of the patients with extrinsic AD…
Fig. 13.1 Cohort questionnaire study of Osaka University students with AD (n = 288) who were followed for 4 years from 2012 to 2016 Fig. 13.2 The change in patient…
Fig. 12.1 Homeostasis of physiological skin barrier and S. aureus-derived virulence factors. KLK kallikrein, LEKTI lymphoepithelial Kazal-type-related inhibitor, NMF natural moisturizing factor, SCCE stratum corneum chymotryptic enzyme, SCTE stratum corneum…
Chromosome Locus Population Reference 11q13.5 C11ORF30/LRRC32 (GARP) European [5] 1p21.3 FLG Chinese Han [6] 5q22.1 TMEM232/SLC25A46 20q13.33 TNFRSF6B/ZGPAT 11q13.1 OVOL1 European [9] 19p13.2 ACTL9 5q31.1 KIF3A/RAD50/IL13 …
Organ Symptoms Skin Erythema, urticaria, angioedema, pruritus, burning, sensation, eczema Mucous membrane Eye symptoms: Conjunctival hyperemia and edema, pruritus, lacrination, blepharedema Nasal symptoms: Rhinorrhea, nasal congestion, sneezing Oral symptoms: Discomfort/swelling…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_29 29. Clinical Questions: Lifestyle of Japan and Atopic Dermatitis Takeshi Nakahara1 (1) Division of Skin Surface…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_22 22. Drug Therapy: Systemic Norito Katoh1 (1) Department of Dermatology, Graduate School of Medical Science, Kyoto…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_21 21. Management: Drug Therapy—Ointment Takahiro Satoh1 (1) Department of Dermatology, National Defense Medical College, 3-2 Namiki,…
Fig. 6.1 Scheme of a cornified layer barrier: the lamella granules and the keratohyalin granules in the epidermis play important roles in the formation of a mature stratum corneum. The…
Fig. 7.1 Major Th2-related cytokines. Th2 cells secrete various cytokines. IL-4 and IL-13 promote Th2 differentiation, IgE generation, and inflammation and disrupt epidermal barrier function. IL-5 is implicated in eosinophil…
