Pediatric Graft-Versus-Host Disease
Host variables Recipient age <1 or >10 years [10] Malignancy as indication for transplant, as well as features of more advanced disease (WBC >50 × 109/L and cytogenetic abnormalities t(4;11),…
Atypical Manifestations of Graft-Versus-Host Disease
Common manifestations Atypical manifestations aGVHD cGVHDa aGVHD cGVHD Maculopapular rash Poikiloderma Eczematous eruptions (contact dermatitis [2], eczema craquele [3]) Eczematous eruptions [4, 5] (atopic dermatitis [6], eczema craquele [7], and…
Clinical Presentation of Acute Cutaneous Graft-Versus-Host Disease
Fig. 3.1 Erythema of the face with accentuation of the ear Fig. 3.2 Erythema of the ear Fig. 3.3 Palmar erythema Fig. 3.4 Palmar erythema (Note microvesicles that herald edema.)…
Histopathology of Cutaneous Graft-Versus-Host Disease
Lerner grading system [11] Horn grading system [7] Grade 0 Normal skin or unrelated cutaneous disease Grade 1 Vacuolar alteration Vacuolar alteration Grade 2 Spongiosis and dyskeratosis (eosinophilic bodies)…
Diagnosis, Staging, and Treatment of Chronic Graft-Versus-Host Disease
Fig. 10.1 Poikilodermic cGVHD on the neck and upper chest Fig. 10.2 Lichen planus–like chronic graft-versus-host disease (cGVHD). (a) Woman with lichen planus–like cGVHD on the face. (b) Man with…
Dermal and Subcutaneous Chronic Graft-Versus-Host Disease
Fig. 8.1 Shiny, hypopigmented plaques with satellite plaques over the gluteal fold, representing superficial dermal chronic graft-versus-host disease (cGVHD) of the lichen sclerosus type Deep Dermis: Morpheaform Type The classic…
Clinical Presentation of Mucosal Acute and Chronic Graft-Versus-Host Disease
Fig. 4.1 Ocular graft-versus-host disease. Ocular GVHD can affect almost every structure of the eye. Distinctive characteristics of chronic ocular GVHD include keratoconjunctivitis sicca, confluent areas of punctate keratopathy, and…
Wound Care in the Management of Chronic Graft-Versus-Host Disease
Fig. 11.1 Cleansing daily with soap and warm water should be encouraged for patients with sclerotic chronic GVHD. Before (a) and after (b); 2 days of soap and water cleansing…
Grading and Treatment of Acute Graft-Versus-Host Disease
Category Symptoms after DLI or HSCT Acute features Chronic features Classic acute < 100 days Yes No Persistent, recurrent and late-onset > 100 days Yes No Overlap > 100 days…
Overview of Hematopoietic Cell Transplantation
Fig. 1.1 Increasing numbers of patients are undergoing allogeneic hematopoietic stem cell transplantation (HSCT) every year (Adapted from Pasquini and Zhu [1]; with permission) Historical Perspective Pioneering experimentation by Jacobson…
