Definition Atopic dermatitis is a pruritic, eczematous dermatitis; its symptoms chronically fluctuate with remissions and relapses. Most individuals with atopic dermatitis have atopic diathesis Atopic diathesis: (1) personal or family…
AD AR BA FA Number of patients 3068 4933 2060 1787 No complications 1320 (43.0%) 2976 (60.3%) 784 (38.1%) 623 (34.9%) Complication AD – 1174 (23.8%) 675 (32.8%) 714…
Fig. 26.1 Partial cellular and molecular immunological mechanisms in lesional skin of AD. Factors surrounded by red square are targets of therapeutic approaches described in this manuscript. ‘Acute’ shows acute…
Fig. 24.1 Causes and exacerbating factors. Since causes and exacerbating factors vary among patients, care should be taken to identify them sufficiently for each patient before taking removal measures. Modified…
Diagnostic term Author Mycosis sive eczema flexurarum Hebra (1884) Lichen simplex chronicus disseminatus Vidal (1886) Neurodermite disseminatus Brocq and Jacquet (1891) Prurigo diathetique eczemato-lichenienne Besnier (1892) Neurodermite diffuse Brocq (1902)…
Fig. 25.1 Conceptual illustration of “absenteeism” and “presenteeism” There are several assessment procedures for measuring patients’ work productivity. Those procedures share core assessment domains with each other. The major shared…
Fig. 23.1 Proportions of infants who did not have AD/eczema. Kaplan-Meier plots show the proportions of infants in the intervention (circle) and control (triangle) groups with AD/eczema during the first…
Fig. 15.1 AD spectrum encompassing extrinsic and intrinsic AD. AD can be divided into barrier-disrupted, high-IgE extrinsic type and barrier-preserved, normal-IgE intrinsic type. Some of the patients with extrinsic AD…
Fig. 13.1 Cohort questionnaire study of Osaka University students with AD (n = 288) who were followed for 4 years from 2012 to 2016 Fig. 13.2 The change in patient…
Fig. 12.1 Homeostasis of physiological skin barrier and S. aureus-derived virulence factors. KLK kallikrein, LEKTI lymphoepithelial Kazal-type-related inhibitor, NMF natural moisturizing factor, SCCE stratum corneum chymotryptic enzyme, SCTE stratum corneum…
