Clinical Diagnosis

Jul 13, 2017 by in Dermatology Comments Off on Clinical Diagnosis

Fig. 3.1 Classic examples of lentigo maligna (a) on the cheek in a 60 year old female, (b) on the nasal tip in an 83 year old male, (c) and…

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Emerging Novel Non-invasive Imaging

Jul 13, 2017 by in Dermatology Comments Off on Emerging Novel Non-invasive Imaging

Fig. 14.1 RCM feature of LM: nonedged dermal papillae Fig. 14.2 RCM feature of LM: round large pagetoid cells Fig. 14.3 RCM feature of LM: atypical cells at the dermal-epidermal…

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Staged Excision Techniques

Jul 13, 2017 by in Dermatology Comments Off on Staged Excision Techniques

Fig. 6.1 The 2-bladed square technique, (a) The purpose of the initial stage(s) is to define the lesion perimeter. The peripheral wound is sutured, (b) Tissue is processed to examine…

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Mohs Surgery for Lentigo Maligna Melanoma

Jul 13, 2017 by in Dermatology Comments Off on Mohs Surgery for Lentigo Maligna Melanoma

Fig. 7.1 Immunohistochemical stains for melanocytes during Mohs surgery. (a) Hematoxylin and eosin-stained frozen section of melanoma in situ (magnification, 20×) with a large nest of melanocytes (blue arrow). The…

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Pathologic Diagnosis

Jul 13, 2017 by in Dermatology Comments Off on Pathologic Diagnosis

Fig. 5.1 Lentigo maligna. Severe solar elastosis with increased density of junctional melanocytes (a), asymmetric nests (a–c), adnexal involvement (a, b, d), and cytologic atypia of melanocytes (c, d) Fig….

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Role of Radiation

Jul 13, 2017 by in Dermatology Comments Off on Role of Radiation

Radiation quality Energy (kV) D50a (mm) Grenz rays (ultrasoft, supersoft, Bucky therapy) 10–20 0.2–1.0 Soft x-ray 20–100 1–20 Superficial x-ray (low voltage x-ray therapy) 60–150 7–10 Orthovoltage therapy (deep x-ray…

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Role of Topical Therapy: Imiquimod

Jul 13, 2017 by in Dermatology Comments Off on Role of Topical Therapy: Imiquimod

Fig. 11.1 Mechanism of action of imiquimod. Multimodal anti-tumoral activity is achieved via: (1) activation of the NF-kB pathway through TLR-7 and 8 signaling, (2) suppression of negative feedback on…

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