Clinical Diagnosis
Fig. 3.1 Classic examples of lentigo maligna (a) on the cheek in a 60 year old female, (b) on the nasal tip in an 83 year old male, (c) and…
Fig. 3.1 Classic examples of lentigo maligna (a) on the cheek in a 60 year old female, (b) on the nasal tip in an 83 year old male, (c) and…
Fig. 14.1 RCM feature of LM: nonedged dermal papillae Fig. 14.2 RCM feature of LM: round large pagetoid cells Fig. 14.3 RCM feature of LM: atypical cells at the dermal-epidermal…
Fig. 6.1 The 2-bladed square technique, (a) The purpose of the initial stage(s) is to define the lesion perimeter. The peripheral wound is sutured, (b) Tissue is processed to examine…
Fig. 17.1 Irregular brown patch on the left cheek in background of solar lentigines; biopsy sites marked in purple Fig. 17.2 Melanoma in situ of the lentigo maligna type: confluent…
Fig. 7.1 Immunohistochemical stains for melanocytes during Mohs surgery. (a) Hematoxylin and eosin-stained frozen section of melanoma in situ (magnification, 20×) with a large nest of melanocytes (blue arrow). The…
Fig. 5.1 Lentigo maligna. Severe solar elastosis with increased density of junctional melanocytes (a), asymmetric nests (a–c), adnexal involvement (a, b, d), and cytologic atypia of melanocytes (c, d) Fig….
Radiation quality Energy (kV) D50a (mm) Grenz rays (ultrasoft, supersoft, Bucky therapy) 10–20 0.2–1.0 Soft x-ray 20–100 1–20 Superficial x-ray (low voltage x-ray therapy) 60–150 7–10 Orthovoltage therapy (deep x-ray…
Fig. 11.1 Mechanism of action of imiquimod. Multimodal anti-tumoral activity is achieved via: (1) activation of the NF-kB pathway through TLR-7 and 8 signaling, (2) suppression of negative feedback on…
Fig. 18.1 (a) Lentigo maligna on left cheek with brisk inflammatory response after a 12-week course of imiquimod. (b) Clinical clearance of lentigo maligna 4 months after completion of imiquimod…
Fig. 13.1 (a) 95 year old male presented with a LM on the nasal tip. (b, c) An excision with narrow margins was performed and repaired with a porcine xenograft…