Regardless of the etiology of Cushing’s disease or Cushing’s syndrome, the clinical manifestations are caused almost entirely by excessive cortisol production in the zona fasciculata of the adrenal gland. Cortisol…
Treatment: Therapy needs to be individualized for each patient. Those with seizure disorders and CNS tumors require the expertise of a neurologist or neurosurgeon or both. Antiseizure medications are frequently…
Type II neurofibromatosis has a completely different phenotype than type I disease, with some overlap. Onset of disease is often not until the second or third decade of life. The…
Patients with type II disease should have screening MRI studies of the brain and the rest of the central nervous system to look for schwannomas. Type II disease, because of…
Treatment: All patients with Marfan syndrome should be monitored directly by a cardiologist and a cardiothoracic surgeon as needed. Routine echocardiograms and evaluations for aortic aneurysms are required. β-Blockade has…
Treatment: Cushing’s syndrome of exogenous origin requires removal of the responsible agent. In most cases, this is difficult, because these patients often require the life-saving exogenous corticosteroids (e.g., after transplantation)….
Treatment: BCCs tend to be multiple. Routine skin examinations and prompt removal of basal cell skin cancers help decrease the size of scarring and disfigurement resulting from surgery. All patients…
Oral systemic agents are also used for moderate to severe psoriasis. Methotrexate taken on a weekly basis has been used for years. Oral cyclosporine has been used with great success…
Guttate psoriasis is a variant of psoriasis that can occur after an infection, most notably a streptococcal bacterial infection. The guttate lesions develop soon after or during the infection and…
Pathogenesis: Psoriasis is an autoimmune disease caused by an abnormality within the cells of the immune system. There is a genetic susceptibility, and the human leukocyte antigen (HLA) Cw6 locus…
