Fig. 7.1 Immunohistochemical stains for melanocytes during Mohs surgery. (a) Hematoxylin and eosin-stained frozen section of melanoma in situ (magnification, 20×) with a large nest of melanocytes (blue arrow). The…
Fig. 5.1 Lentigo maligna. Severe solar elastosis with increased density of junctional melanocytes (a), asymmetric nests (a–c), adnexal involvement (a, b, d), and cytologic atypia of melanocytes (c, d) Fig….
Radiation quality Energy (kV) D50a (mm) Grenz rays (ultrasoft, supersoft, Bucky therapy) 10–20 0.2–1.0 Soft x-ray 20–100 1–20 Superficial x-ray (low voltage x-ray therapy) 60–150 7–10 Orthovoltage therapy (deep x-ray…
Fig. 11.1 Mechanism of action of imiquimod. Multimodal anti-tumoral activity is achieved via: (1) activation of the NF-kB pathway through TLR-7 and 8 signaling, (2) suppression of negative feedback on…
Fig. 18.1 (a) Lentigo maligna on left cheek with brisk inflammatory response after a 12-week course of imiquimod. (b) Clinical clearance of lentigo maligna 4 months after completion of imiquimod…
Fig. 13.1 (a) 95 year old male presented with a LM on the nasal tip. (b, c) An excision with narrow margins was performed and repaired with a porcine xenograft…
Age Chronically sun exposed areas of sun-damaged skin Number of lentigenes Number of AKs History of previous keratinocyte carcinomas Genetic conditions associated with LM include xeroderma pigmentosum, oculocutaneous albinism, Werner…
© Springer International Publishing Switzerland 2017Kishwer S. Nehal and Klaus J. Busam (eds.)Lentigo Maligna Melanoma10.1007/978-3-319-43787-3_1 1. Introduction Karen L. Connolly1 , Klaus J. Busam2 and Kishwer S. Nehal1 (1) Dermatology, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022,…
