Graft Versus Host Disease (GVHD)
Category Time of symptoms after HCT or DLI Presence of acute GVHD features Presence of chronic GVHD features Acute GVHD Classic acute GVHD ≤100 d Yes No Persistent, recurrent, or…
Macrophages
Marker Function Comments Classically activated macrophage (M1 macrophage) IL-6 Promotes inflammatory response Induced by IFN-γ IL-12 Induces Th1 development Induced by IFN-γ iNOS Produces NO to kill microorganisms Induced by…
Anaphylaxis
© Springer Japan 2016Kenji Kabashima (ed.)Immunology of the Skin10.1007/978-4-431-55855-2_26 26. Anaphylaxis Eishin Morita1 (1) Department of Dermatology, Shimane University Faculty of Medicine, Enya-cho 89-1, Izumo 693-8501, Japan Eishin Morita Email: emorita@med.shimane-u.ac.jp Abstract Anaphylaxis was first…
Cutaneous Adverse Drug Reactions: Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
Fig. 24.1 (a) The hapten-modified peptide is recognized and stimulates T cells. The hapten may also have the ability to activate the innate immune system. (b) The drug binds to…
Stratum Corneum
Fig. 2.1 Epidermal structures. Insert, electron micrograph: Murine skin was fixed in Karnovsky’s fixative overnight, and postfixed with 0.25 % ruthenium tetroxide. Ultrathin sections were examined using an electron microscope 2.2…
Langerhans Cells and Dermal Dendritic Cells
Fig. 4.1 Cutaneous dendritic cells in the steady state and in the inflammatory state. LCs Langerhans cells, dermal DCs dermal dendritic cells, IDECs inflammatory dendritic epidermal cells, Tip-DCs tumor necrosis…
Hair Follicles
Fig. 13.1 The structure of the hair follicle and the hair cycle. Fully grown anagen hair follicle extends deeper into subcutaneous fat. Anagen hair follicle is divided into five anatomical…
γδ T Cells
Fig. 6.1 Dendritic epidermal T cells (DETCs). Epidermal sheet from a normal adult mouse stained with an anti-γδ TCR monoclonal antibody (green, DETCs) and DAPI (blue, mainly keratinocytes) Unlike conventional…
Neutrophils
Fig. 9.1 Neutrophils in the skin. Schematic representation of molecular and cellular processes initiated during neutrophil antibacterial response in the dermis. The antibacterial response is initiated by sensing of DAMPs…
Lymphatic Vessels
Fig. 12.1 Lymphatic vessels and valves shown by enhanced green fluorescent protein driven by Prox1 promoter in transgenic mice. (a) Cutaneous lymphatic vessels are found in dorsal skin 1 week after…
