© Springer International Publishing Switzerland 2017Anthony A. Gaspari, Stephen K. Tyring and Daniel H. Kaplan (eds.)Clinical and Basic Immunodermatology10.1007/978-3-319-29785-9_24 24. Immunology of Acne Galen T. Foulke1 and Amanda M. Nelson2 (1) Department of Dermatology, Pennsylvania State Hershey Medical Center, Hershey,…
Neuromediator Source Receptor Primary function Substance P Sensory nerve fibers Meissner corpuscles Perivascular nerves Mast cells Monocytes Eosinophils Tachykinin (neurokinin) receptor Mediates erythema and edema Increases histamine and TNF-α release…
Fig. 1.1 LC and DC populations in human skin. (a) LC and DC residing in human skin in the steady state and (b) infiltrating the skin during inflammation. The main…
JAML–CAR DETC express JAML (junction adhesion molecule like protein) at low level in steady state and upregulate its expression upon activation. The binding partner of JAML, the coxsackie and adenovirus…
TLR Disease Comments 1 Tuberculoid TLR1 favors Th1 phenotype [11] Leprosy TLR1 I602S mutation protects from M. leprae [12] Psoriasis TLR1 expression increased in keratinocytes [13] Lyme disease TLR1 polymorphism…
Acute phase proteins, cytokines and chemokines Adhesion molecules and ECM components Factors directly affecting metabolism α1-acid-glycoprotein α2-macroglobulin Adipocyte fatty acid binding protein (aP2) Chemerin Collagen I, III, IV, VI Adiponectin…
Fig. 9.1 Dendritic cell paradigm during steady state and activation. Cutaneous dendritic cells (DC) include Langerhans cells (LC) in the epidermis and CD11b + and CD103+ dermal dendritic cells (dDC)…
Mouse Human Unique Shared Unique Shared ILC1 NK IL-12Rβ2 CD127 (not on NK) CD90 (not on NK, ILC1) CD117 (not on NK, ILC1, NCR- ILC3) IL-12Rβ2 CD127 (not on…
TLR Ligand [102, 103] TLR1 Lipopeptide (Pam3csk4) TLR2 Peptidoglycan, Zymosan, LTA, Lipopeptide (Pam3csk4) TLR3 PolyI:C (dsRNA) TLR4 LPS, RSV protein F, Mycobacterium tuberculosis TLR6 Peptidoglycan, Zymosan TLR9 Bacterial DNA (CpG…
