, Camille E. Introcaso3, Stephen K. Richardson4 and Alain H. Rook5 (1) Department of Dermatology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (2) Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA (3)…
Fig. 48.1 Chemical structure of cortisol. Note the four-ring structure and the hydroxyl group at position 11 Modifications of the basic GCS structure result in agents with variant potency, mineralocorticoid…
Angiogenesis inhibitors Angiostatin Naturally occurring protein found in some animal species. Angiostatin is known to be cleaved by MMPs [2]. Angiostatin binds to endothelial cell surface adenosine triphosphate (ATP) synthase…
Fig. 27.1 Urticarial lesions (By permission of B Cohen and CU Lehmann, DermAtlas, Johns Hopkins University, 2000–2007) Clinical Features of Urticaria Clinically, urticarial lesions are intensely pruritic and can appear…
Phenotypes Major immune cells Major cytokines or cytotoxic mediators MPE CD4+ > CD8+ T cells IFN-γ, TNF-α, IL-4, IL-5, perforin/granzyme B DRESS CD4+ > CD8+ T cells, eosinophils IFN-γ, TNF-α,…
Fig. 20.1 Represents the major steps in the infection of a CD4 lympocyte with HIV. Anti-retroviral drugs have been developed to target various steps in the replication of HIV Virologic,…
Fig. 34.1 Dermatitis herpetiformis. (a) Excoriated papules and papulo-vesicles on elbows and knees of a DH patient. (b) Urticarial plaques of DH Patients with mild disease usually have involvement of…
Fig. 16.1 S. aureus cellulitis on the lower leg. The involved skin characteristically shows signs of inflammation, including erythema, warmth, edema, and pain (Photograph is courtesy of the Victor D….
Fig. 35.1 Diagram of the hemidesmosome. Individual proteins comprise the hemidesmosome and many of these proteins serve as antigenic targets in clinical variants along the pemphigoid spectrum Characterization of autoantibodies…
