Overview: Immunology of the Skin
Fig. 1.1 Immunohistochemistry of the skin with S100. The skin consists of the corneum, epidermis, and dermis. The epidermis contains Langerhans cells, and the dermis contains dermal dendritic cells, which…
Dermatology
Viral Infection
dsDNA viruses Poxviridae Molluscum contagiosum virus Herpesviridae α: human herpesvirus 1, 2, 3 (HSV-1, HSV-2, VZV) β: human herpesvirus 5, 6, 7 (HCMV, HHV-6, HHV-7) γ: human herpesvirus 4, 8…
Atopic Dermatitis: Common Extrinsic and Enigmatic Intrinsic Types
Fig. 21.1 AD spectrum based on extrinsic and intrinsic AD dichotomy. AD can be divided into barrier-disrupted high-IgE extrinsic type and barrier-nondisrupted normal IgE intrinsic type. Some of the patients…
Platelets
Chemokines CXCL1 (growth-related oncogene-α) CXCL4 (PF-4) CXCL5 (epithelial neutrophil-activating peptide-78) CXCL7 (β-TG) CXCL8 (interleukin-8) CXCL12 (stromal cell-derived factor-1) CCL1 (I-309) CCL2 (macrophage chemotactic protein-1) CCL3 (macrophage inflammatory protein-1α) CCL5 (RANTES)…
Innate Immunity
Group PRR PAMPs and DAMPs Source of PAMPs and DAMPs TLRs TLR1/2 Triacyl lipopeptides Bacteria TLR2 Peptidoglycan Gram (+) bacteria, e.g., S. aureus Glycolipids Mycobacteria Phosphilipomannan C. albicans TLR3 dsRNA…
Cutaneous Lymphomas
Fig. 29.1 Electron microscopy of a malignant T cell in a patient with Sézary syndrome with characteristic prominent polychromatic cerebriform nucleus. Scale bar 2 μm From an immunological perspective, patients with…
Photodermatology: Therapeutic Photomedicine for Skin Diseases
Fig. 30.1 Dual action mechanisms for phototherapy-apoptosis and immune suppression 30.3.1 Regulatory T Cells (Treg) Induction Narrowband UVB therapy generally induces a relatively long remission period of approximately 4–6 months in…
C-Type Lectin Receptors
Fig. 17.1 Domain structure for the traditional seven (I–VII) groups of vertebrate CTLs. Domain names are listed in the box The natural killer (NK) receptor family (group V) contains a…
