Using Intravenous Immunoglobulins in Autoimmune Bullous Diseases
Fig. 52.1 Grams of IVIG issued by discipline over time in Australia [2] In Australia, 2003, the National Blood Agreement (NBA) was created. This led to the creation of the…
Dermatology
Clinical Features of Bullous Systemic Lupus Erythematosus
Fig. 41.1 Tense bullae typical of bullous systemic lupus erythematosus on a 21-year-old African American female Fig. 41.2 The vesicles and bullae in bullous systemic lupus erythematosus typically progress to…
Azathioprine
Fig. 47.1 Structure of azathioprine. The dashed line marks the cleavage site 47.2 Molecular Mechanism and Metabolism Azathioprine is a purine analogue prodrug that requires metabolic conversion into active compounds….
Pathogenesis of Epidermolysis Bullosa Acquisita
Fig. 12.1 Demonstration of the pathogenicity of anti-COL7 autoantibodies in vitro, ex vivo, and in vivo. (a) Schematic diagram of reactive oxygen species (ROS) induced by immune complexes (IC) generated…
Epidermolysis Bullosa Acquisita
Fig. 40.1 Characteristic cutaneous lesions on trauma-prone surfaces in a classical form of EBA: (a) tense bullae on normal skin of an ankle, (b) few post-bullous erosions on the back…
Junctional Epidermolysis Bullosa with Renal and Respiratory Involvement: Integrin α[Alpha]3 Mutations
Skin Clinical features Blisters, nail dystrophy, sparse hair Immunomapping Focal disruption of the dermo-epidermal junction, cleavage within the plane of the basement membrane Transmission electron microscopy Thin lamina densa, discontinuous…
Future Therapies for Epidermolysis Bullosa
© Springer-Verlag Berlin Heidelberg 2015Dédée F. Murrell (ed.)Blistering Diseases10.1007/978-3-662-45698-9_76 76. Future Therapies for Epidermolysis Bullosa Jaehwan Kim1, 2 , Wenfei Yan2 and Dédée F. Murrell2 (1) Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA (2) Department…
The Pathogenesis and Management of Pruritus in Epidermolysis Bullosa
© Springer-Verlag Berlin Heidelberg 2015Dédée F. Murrell (ed.)Blistering Diseases10.1007/978-3-662-45698-9_75 75. The Pathogenesis and Management of Pruritus in Epidermolysis Bullosa Frank P. Brennan1 (1) Department of Palliative Care, St. George Hospital, Sydney, NSW, Australia Frank P. Brennan…
Acantholytic Forms of Epidermolysis Bullosa
Fig. 28.1 Transmission electron microscopy of a desmosome and schematic representation of the main molecular components Genetic disorders affecting the desmosomal assembly, structure or integrity disrupt not only the intercellular…
Supportive Care: Bathing, Wound Care, Nutrition, Pain and Itch Management, Psychosocial Support, Palliation
Type of dressing Common brands Foams Mepilex and Mepilex Lite (Molnlycke), PolyMem (Ferris Mfg) Modified absorbent pads Telfa (Kendall Comp Ltd), Restore (Hollister), ETE (Molnlycke), Mesorb (Molnlycke) Lipidocolloid dressings Urgotul…
