, Jane Tomimori1, Sofia Beatriz Machado de Mendonça1 and Douglas Antonio Rodrigues1 (1) Universidade Federal de São Paulo, São Paulo, Brazil The recognition of elementary skin lesions is the most important part of clinical examinations for…
, Jane Tomimori1, Sofia Beatriz Machado de Mendonça1 and Douglas Antonio Rodrigues1 (1) Universidade Federal de São Paulo, São Paulo, Brazil 6.1 Seborrheic Keratosis Seborrheic keratosis is a common benign proliferation of epidermal cells . This…
, Jane Tomimori1, Sofia Beatriz Machado de Mendonça1 and Douglas Antonio Rodrigues1 (1) Universidade Federal de São Paulo, São Paulo, Brazil Thinking of the body, you can mistakenly face it as purely biological, a universal patrimony…
Innate Adaptive Early response to foreign antigens Occurs within days of infection Rapid response is the first line of defense Antigen specific Broad spectrum (not antigen specific) Develops immune memory…
Autoimmune disorders Autoimmune lymphoproliferative syndrome (ALPS) Immune dysregulation, polyendocrinopathy, X-linked syndrome (IPEX) Hematologic malignancy Acute myeloid leukemia Acute lymphoblastic leukemia Chronic lymphocytic leukemia Chronic myeloid leukemia Hodgkin’s lymphoma Multiple myeloma…
Subtypes Most common sites of involvement Cutaneous lichen planus Actinic Sun-exposed areas Annular Male genitalia, intertriginous Atrophic Predominately on lower extremities, may occur on other areas of the body Erosive…
Causes Frequency (%) Idiopathic 40 Infection 22 Drug reaction 20 Connective tissue disease 12 Henoch-Schönlein purpura 10 Malignancy <5 Systemic vasculitis <5 Other systemic disease <5 Initial Workup of Cutaneous…
Pemphigus vulgaris Pemphigus vegetans Pemphigus foliaceus Pemphigus erythematosus: localized Fogo selvagem: endemic Paraneoplastic pemphigus Drug-induced pemphigus IgA pemphigus Pathogenesis Pemphigus Target Antigens are Desmogleins The hallmark of pemphigus is the…
Fig. 19.1 Possible pathways for immunologic responses stimulated by fungi. (a) Most fungi are detected and destroyed within hours by innate nonspecific defense mechanisms mediated by phagocytes such as macrophages,…
