Glowing in the Dark
Reflectance confocal microscopy patterns and structures of clinically dark lesions are described. Because many of the dark lesions have melanin in superficial skin layers these lesions show great semiology by…
Lentigo Maligna, Macules of the Face, and Lesions on Sun-Damaged Skin
Distinguishing lentigo maligna (LM) and lentigo maligna melanoma (LMM) from background pigmented non-melanoma lesions is challenging. The field of solar damage can obscure clinical assessment, and diagnostic ambiguities are created…
Discriminating Nevi from Melanomas
Reflectance confocal microscopy (RCM) together with dermoscopy enables improved differentiation of melanomas from most nevi. The resulting high sensitivity for detecting melanoma with RCM is complemented by a concomitant increased…
Opening a Window into Living Tissue
The knowledge of histopathology and in vivo reflectance confocal microscopy correlation has several potential applications. Reflectance confocal microscopy can be performed in all skin tumors, and in this article, the most…
Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors
The use of reflectance confocal microscopy (RCM) and other noninvasive imaging devices can potentially streamline clinical care, leading to more precise and efficient management of skin cancer. This article explores…
Reflectance Confocal Microscopy Clinical Applications: The Skin from Inside
Jane M. Grant-Kels, MD, Editor Giovanni Pellacani, MD, Editor Caterina Longo, MD, PhD, Editor We are constantly seeking ways to improve our clinical acumen and reduce unnecessary biopsies. Reflectance confocal microscopy…
Distinct Fibroblasts in the Papillary and Reticular Dermis
Human skin wounds heal largely by reparative wound healing rather than regenerative wound healing. Human skin wounds heal with scarring and without pilosebaceous units or other appendages. Dermal fibroblasts come…
Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation…
Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinomas (SCCs) account for up to 10,000 deaths annually in the United States. Most of the more than 700,000 SCCs diagnosed are cured by excision with clear…
