Role of Topical Therapy: Imiquimod
Fig. 11.1 Mechanism of action of imiquimod. Multimodal anti-tumoral activity is achieved via: (1) activation of the NF-kB pathway through TLR-7 and 8 signaling, (2) suppression of negative feedback on…
Case C: Topical Treatment of Lentigo Maligna: A Case Comparison
Fig. 18.1 (a) Lentigo maligna on left cheek with brisk inflammatory response after a 12-week course of imiquimod. (b) Clinical clearance of lentigo maligna 4 months after completion of imiquimod…
Incorporating Patient Preferences and Quality of Life
Fig. 13.1 (a) 95 year old male presented with a LM on the nasal tip. (b, c) An excision with narrow margins was performed and repaired with a porcine xenograft…
Epidemiology and Natural History
Age Chronically sun exposed areas of sun-damaged skin Number of lentigenes Number of AKs History of previous keratinocyte carcinomas Genetic conditions associated with LM include xeroderma pigmentosum, oculocutaneous albinism, Werner…
Introduction
© Springer International Publishing Switzerland 2017Kishwer S. Nehal and Klaus J. Busam (eds.)Lentigo Maligna Melanoma10.1007/978-3-319-43787-3_1 1. Introduction Karen L. Connolly1 , Klaus J. Busam2 and Kishwer S. Nehal1 (1) Dermatology, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, New York, NY 10022,…
Potential Role of Angiogenesis and Lymphangiogenesis in Atopic Dermatitis: Evidence from Human Studies and Lessons from an Animal Model of Human Disease
Major criteria (Required for diagnosis) Any pruritic skin condition in the past 12 months Minor criteria (Require 3 of the following) Age of onset younger than 2 yearsa History of…
The Role of Angiogenesis in the Development of Psoriasis
Fig. 3.1 Plaque psoriasis. Archives of the Ambulatório de Psoríase, Pontifícia Universidade Católica de Campinas Fig. 3.2 Plaque psoriasis. Archives of the Ambulatório de Psoríase, Pontifícia Universidade Católica de Campinas…
Angiogenesis and Pathogenesis of Port Wine Stain and Infantile Hemangiomas
Fig. 8.1 (a) Adolescent male with PWS; (b) same male with PWS at 42 years of age. Note vascular nodules and soft tissue hypertrophy in (b) (Reprinted with permission from…
Chemoprevention and Angiogenesis
Fig. 7.1 Cancer transformation is a multi-stage process and chemopreventive strategies should aim to target the exposure (1), and/or initial cancer formation (2) or (3) cancer promotion This ROS induced…
Angiogenesis and Nonmelanoma Skin Cancer
(1) Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA (2) Department of Dermatology, Division of Dermatologic Surgery, Wilmot Cancer Center, University of Rochester, 400 Red Creek Drive, Suite 200,…
